hrp0098fc4.5 | Adrenals and HPA Axis 1 | ESPE2024

3D printed, personalized hydrocortisone for hypocortisolemia.

Ayyoubi Sejad , van den Akker Erica , Feelders Richard , Ruijgrok Liesbeth

Introduction: The current standard of care (SOC) for adrenal insufficiency (AI) is suboptimal due to fluctuating cortisol plasma concentrations. The sub- and supraphysiological cortisol levels, combined with the multi-day tablet intake, are associated with negative health outcomes and a poor quality of life. Furthermore, there is a high interindividual difference in the cortisol need, demanding a personalized approach. Pharmaceutical 3D printing (3DP) allows f...