hrp0092p3-178 | Growth and Syndromes (to include Turner Syndrome) | ESPE2019

Long-Term Effect of Growth Hormone Treatment on the Onset and Progression of Scoliosis in Children with Prader-Willi Syndrome

Grootjen Lionne , Donze Stephany , Damen Layla , Rutges Joost , Hokken-Koelega Anita

Context: Most children with Prader-Willi syndrome (PWS) develop scoliosis. Scoliosis has a prevalence of 80% in children with PWS older than 10 years, who were not treated with growth hormone (GH). GH is an approved treatment for children with PWS and improves psychomotor development and body composition. The onset and progression of scoliosis are generally associated with an accelerated growth velocity and GH treatment might cause accelerated growth. Sinc...