ESPE Abstracts

Severe early-onset obesity (SEOO) increases the likelihood of obesity persisting into adulthood. Leptin (LEP), a hormone primarily produced in adipose tissue, plays a crucial role in regulating energy balance. When assessing young children with SEOO, it is important to consider abnormalities in the leptin-melanocortin pathway. Our study aim ed to identify children with SEOO who may have LEP deficiency or biologically inactive leptin by analyzing leptin and biologically active ...