hrp0092p1-204 | Fetal, Neonatal Endocrinology and Metabolism (to include Hypoglycaemia) (1) | ESPE2019

Risk Factors for Brain Injury After Transient or Persistent Hyperinsulinemic Hypoglycemia in Neonates

Roeper Marcia , Dafsari Roschan Salimi , Kummer Sebastian , Klee Dirk , Mayatepek Ertan , Sabir Hemmen , Meissner Thomas

Background: Aim of this study was to identify possible explanations why despite improved treatment options brain damage still occurs in neonates with transient or persistent hyperinsulinism. This study might serve as a basis for future research to improve the management of neonatal hypoglycemia reducing brain injury in these children.Material and Methods: A retrospective medical chart review was conducted at the Universi...

hrp0092p2-144 | Fetal, Neonatal Endocrinology and Metabolism (to include Hypoglycaemia) | ESPE2019

Glucagon Therapy In Preterm Infants With Hyperinsulinemic Hypoglycaemia

Salimi Dafsari Roschan , Roper Marcia , Groß Maximilian , Wiechers Cornelia , Sabir Hemmen , Mayatepek Ertan , Meissner Thomas

Background: The treatment of preterms with hyperinsulinemic hypoglycaemia is a well-known challenge. One of the difficulties of the therapy is the excessive application of intravenous fluids to compensate high carbohydrate needs. There are various drug alternatives such as glucagon, diazoxide or somatostatin analogues apart from intravenous glucose application.Hypothesis: Intravenous or continuous subcutaneous glucagon t...

hrp0086p2-p57 | Adrenal P2 | ESPE2016

False-Positive Increases of Steroid Hormone Precursors Mimicking 11β-Hydroxylase-Deficiency in a Preterm Infant

Welters Alena , Roschinger Wulf , Franzel Julia , Sabir Hemmen , Mayatepek Ertan , Meissner Thomas , Kummer Sebastian

Background: In premature and small-for-date infants, immature adrenal enzyme activity, adrenal stress responses and impaired hepatic clearance may lead to mild to moderate false-positive increases of steroid hormone precursors. This complicates screening programs for congenital adrenal hyperplasia (CAH) in these patients.Objective and hypotheses: We present a preterm female infant (born at 33 weeks of gestation) who’s newborn screening 55 h after bi...