hrp0092p1-313 | Diabetes and Insulin (2) | ESPE2019

Familial Versus Non-Familial Type-2 Diabetes Mellitus in Children and Adolescents: Clinical and Biochemical Data.

Alyafei Fawzia , Soliman Ashraf , Sabt Aml , Aldarsy Nagwa

Familial clustering of type-2 diabetes is well-known. In adults, the prevalence of diabetes is higher among patients with diabetic parents. The Framingham offspring study found that maternal and paternal diabetes conferred equal risk for offspring type-2 diabetes.Objectives: We conducted this study to compare the clinical characteristics of children and adolescents with family history of type- 2 diabetes mellitus, in one or both parents,...

hrp0092p2-183 | Growth and Syndromes (to include Turner Syndrome) | ESPE2019

The Prevalence of Celiac Disease (CD) in Children with Type 1 Diabetes Mellitus (T1D); Does CD Adversely Affect Linear Growth in these Children?

Alyafei Fawzia , Soliman Ashraf , Sabt Aml , Elsayed Nagwa

The prevalence of biopsy-proven CD in T1D in pediatric populations widely ranges between 2.6 in Finland to 16.4 in Algeria. Many patients with CD and T1D are either asymptomatic (silent CD) or present with only mild symptoms. CD children may be less likely to show overt growth failure but can have weight and height measures at a lower growth percentile and complain of nonspecific symptoms, including anorexia and lassitude.Aim; Patients and Methods:<p...

hrp0082p3-d3-751 | Diabetes (4) | ESPE2014

Continuous Glucose Monitoring vs Oral Glucose Tolerance Test and HbA1C in the Evaluation of Glycemic Abnormalities in an Obese Adolescent Before vs After Partial Gastrectomy

Soliman Ashraf , Sabt Aml , Alyafei Fawzia , Eldarsy Nagwa

Background: We compared continuous glucose monitoring (CGMS) (Medtronic) to oral glucose tolerance test (OGTT) and HbA1c in the follow-up of glycemic abnormality in an adolescent girl with morbid obesity and glycemic abnormalities before and after 2 months of partial gastrectomy. This 16-year-old adolescent girl presented with obesity (weight 98 kg, height 158 cm, BMI=39.2 kg/m2), acanthosis nigricans and nocturnal polyuria and polydipsia. Trials to reduce weight th...

hrp0082p3-d2-855 | Growth (3) | ESPE2014

Effect of Cyanotic and Acyanotic Congenital Heart Disease on Placental and Birth Size

Soliman Ashraf , Shatlah Emad , Sabt Aml , Alyafei Fawzia , Alqadi Mohanad

Background: Abnormal cardiac development leading to CHD can be associated with abnormal placental development with abnormal trophoblast invasion and remodeling resulting in abnormal transfer of nutrients and oxygen.Objective and hypotheses: We measured the anthropometric parameters (length, weight, and head circumference) and the placental weight of 49 FT newborns (gestation period >36 weeks) infants with CHD ((cyanotic (n=8) and acyanotic (...

hrp0089p2-p060 | Diabetes &amp; Insulin P2 | ESPE2018

Incidence of Childhood Type 1 and Type 2 Diabetes Mellitus in Qatar between 2012–2016

Alyafei Fawziya , Soliman Ashraf , Alkhalaf Fawziya , Waseef Reem , Abdulkayoum Anas , Sayed Ahmed , Eldarsy Nagwa , Sabt Aml

Introduction: The overall age-adjusted incidence of type 1 diabetes (T1DM) varied from 0.1/100,000 per year in China and Venezuela to 36.8/100,000 per year in Sardinia and 36.5/100,000 per year in Finland. This represents a 350-fold variation in the incidence among the 100 populations Worldwide. In the early 1990s, T2DM it was representing about 3 percent only of pediatric diabetes in the United States, but by 2003, T2DM reached about 20 percent of pediatric diabetes.<p cl...

hrp0089p3-p081 | Diabetes &amp; Insulin P3 | ESPE2018

Prevalence of Beta-cell Antibodies and Associated Autoimmune Diseases in Children and Adolescents with Type 1 (T1DM) vs Type 2 Diabetes Mellitus (T2DM) in Qatar

Alyafei Fawzia , Soliman Ashraf , Alkhalaf Fawziya , Sabt Aml , Waseef Reem , Eldarsy Nagwa , Algamal Mona

Introduction: Type 1 diabetes (T1DM) is an autoimmune disease with abnormal immune responses to specific β-cell autoantigens, resulting in insulin deficiency. Children and adolescents with T1DM may also develop organ-specific autoimmunity. The most frequently reported disorders are thyroid dysfunction and celiac disease. There are limited previous studies on the prevalence of associated autoimmunity, especially multiple, in children with T1DM.Aim: T...

hrp0082p2-d3-438 | Growth Hormone (2) | ESPE2014

Does Priming with Sex Steroids Before GH Stimulation Test Increase the Diagnosis of Normal GH Secretion in Short Children?

Soliman Ashraf , De sanctis Vincenzo , Elgaali Elkhansa , Ahmed Hannah , Sabt Aml , Nassar Randa

Introduction: There is still controversy for priming with sex steroid before GH testing.Objective and hypotheses: We studied GH response to stimulation in 92 children >9 years with idiopathic short stature (HtSDS −2). They were divided randomly into two groups. Children in group 1 (n=50) were primed with premarin in girls and testosterone in boys and those in group 2 were not primed (n=42). All children were tested using stand...