hrp0089p1-p238 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P1 | ESPE2018

Effect of Intrauterine Growth Restriction on Ovarian Follicle Pool

Pampanini Valentina , Germani Daniela , Puglianiello Antonella , Jahnukainen Kirsi , Sahlin Lena , Cianfarani Stefano , Soder Olle

Introduction: A low oxygen and/or nutrient supply to the fetus, resulting in intrauterine growth restriction (IUGR), can affect gonadal development of the offspring and have a potential impact on fertility. Epidemiological studies on subjects born small for gestational age (SGA), as a surrogate measure of IUGR, have reported contradictory results. Data derived from animal models of placental insufficiency are limited.Objective and hypotheses: To investig...

hrp0086rfc4.6 | Pathophysiology of Obesity | ESPE2016

Adipose Tissue – A Source of Hyperandrogenism in Obese Females?

Wagner Isabel V. , Sahlin Lena , Savchuk Iuliia , Svechnikov Konstantin , Soder Olle

Background: Obesity in females is often associated with metabolic complications and hyperandrogenism. However, the source of androgens is not entirely clear.Objectives and hypotheses: Our objective was to find out if adipose tissue (AT) is a site of steroid production during childhood and adolescence, and if this source could add to hyperandrogenism in obese females.Methods: Parametrial and inguinal adipose tissue was collected and...

hrp0092p1-42 | Fat, Metabolism and Obesity | ESPE2019

De-novo and Depot-Specific Androgen Production in Human Adipose Tissue - a Source of Hyperandrogenism in Obese Females

Wagner Isabel Viola , Sahlin Lena , Kulle Alexandra , Klöting Nora , Döbeln Viola , Savchuk Iuliia , Dötsch Jörg , Söder Olle

Background: Obesity in females is often associated with metabolic complications and hyperandrogenism but the role of adipose tissue (AT) in androgen synthesis remains unclear.Aims/Objectives: Employing human subcutaneous and visceral AT and cultured adipocytes, we studied whether AT could be a source of androgens promoting hyperandrogenism in lean and especially in obese females.Methods</st...