hrp0086p2-p159 | Bone & Mineral Metabolism P2 | ESPE2016

Low Bone Mineral Density in Adolescents with Joint Hypermobility

Salehpour Shadab , Setavand Somayeh

Background: Generalized joint hypermobility is quite common and seems to be a risk factor for low bone density.Objective: The goal of this study was to determine the bone mineral density in adolescents with hypermobility syndrome.Materials and methods: In a cross-sectional study, we measured the bone mineral density (BMD) and bone mineral apparent density (BMAD) of 32 children, 13 to 18 years old with benign hypermobility syndrome ...

hrp0086p2-p660 | Growth P2 | ESPE2016

Comparison between Effects of Oral Iron and Vitamin A with Oxandrolone upon Height and Puberty of Children with Constitutional Delay of Growth and Puberty

Pournasiri Zahra , Salehpour Shadab

Background: Constitutional delay of growth and puberty (CDGP) is one of the most common problems of pediatrics. It causes a lot of psychological and social disorders in families. Currently there are a variety of therapies including administration of testosterone enantate, oxandrolone and growth hormone.Objective: The aim of this study, which has been performed as the first in Iran and the second in the world, is the comparison between effects of oral iro...

hrp0095p1-165 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

The Effect of Metformin on the Onset of Menarche and The Final Height of Obese Girls

Salehpour Shadab , Kalantari Fatemeh , Setavand Somayeh

Background/aims: Obese girls experience precocious puberty which could influence their final height. We studied the effect of metformin on their body weight, final height, onset of menarche, and bone age.Methods: In a prospective study, 63 obese girls aged between 8 -13 years old were treated with metformin (500-1000 mg/daily and compared with control at the outpatient pediatric endocrine clinic of Loghman Hakim Hospital...

hrp0084p2-347 | Fat | ESPE2015

A Double-Blind, Placebo-Controlled Comparison of Cinnamon Extract to Metformin Effects upon Insulin Resistance, Apolipoprotein B:Apolipoprotein A1 Ratio, and BMI of Obese Adolescent Girls with Polycystic Ovary Syndrome

Salehpour Shadab , Setavand Somayeh , Onsori Samaneh

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies, affecting 5–10% of population. Insulin resistance, apolipoprotein B:apolipoprotein A1 ratio, and BMI commonly increases in obese PCOS patients and are among the indicators of the disease. On the other hand, metformin and cinnamon are generally believed to control these.Objective and hypotheses: To compare the effects of cinnamon with those of the metformin on in...

hrp0089p2-p055 | Bone, Growth Plate & Mineral Metabolism P2 | ESPE2018

Oxandrolone Improves the Linear Growth and Osteoporosis in Teenage Bays with Osteogenesis Imperfecta

Salehpour Shadab , Setavand Somayeh , Shiari Reza , Reza Yassaee Vahid , Vafadar Mehdi , Tavakoli Saeed

Background: Severe osteogenesis imperfecta (OI) is a disorder characterized by osteoporosis, frequent fractures, progressive deformity and short stature. We determine the effect of oxandrolone on predicted adult height (PAH), fracture incidence and bone mineral density in teenage boys with OI.Methods: In a prospective, double-blind, randomized, placebo-controlled clinical trial, 31 boys (12.1–16.6 years old) who were genetically proved to have OI wi...

hrp0084p1-20 | Bone | ESPE2015

24-Hydroxylase Polymorphism as a Possible Contributor to the Increased 1,25(OH)2D in African Americans

Carpenter Thomas O , Cole David E C , Ardeshirpour Laleh , Salehpour Shadab

Background: States of vitamin D insufficiency are important determinants of rickets, as well as osteoporosis and other common complex disorders like diabetes, cancer, and infectious diseases. Although, serum concentrations of the vitamin D metabolites are primarily driven by vitamin D supply (by diet or cutaneous synthesis), there is emerging evidence to suggest that single nucleotide variants (SNVs) are important genetic determinants.Objective and hypot...