ESPE Abstracts

Objective: Hyperglycemia is the primary metabolic problem of Diabetes Mellitus (DM). DM is characterized by chronic high glucose levels. Chronic hyperglycemia or poor metabolic control of diabetes is associated with increased systemic inflammation and oxidative stress. The rate at which hyperglycemia induces oxidative stress is important in determining strategies for reversing the process and preventing comorbidities. In our study, we aimto evaluate the relati...

Introduction: The production of ischemia-modified albumin (IMA) is associated with the production of reactive oxygen species modifying the metal-binding sites of albumin. IMA is considered a non-specific early biomarker in the evaluation of oxidative stress status. Cortisol is known to trigger anti-inflammatory actions through genomic and non-genomic pathways that eventually lead to decreased production of cytokines, chemokines, and inducible nitric oxide synt...

Introduction: Increased cytokine release, impaired antioxidation and reactive oxygen species (ROS) have been shown in β-cells in pathogenesis of T1DM. Increased ROS leads to formation of covalent bonds between the sulfur atoms, leading to disulphide conversion. Displacement to disulphide form of this thiol/disulphide balance starts the oxidative damage. This study evaluates the thiol/disulphide balance in children with T1DM.Material...