hrp0098p1-149 | Fat, Metabolism and Obesity 3 | ESPE2024

Obstructive sleep apnea impairs insulin clearance and hepatic insulin sensitivity in children and adolescents with obesity

Rosaria Umano Giuseppina , Rondinelli Giulia , Salvatori Alessandra , Petrone Delfina , Di Sessa Anna , Cirillo Grazia , Tricò Domenico , Miraglia del Giudice Emanuele

Introduction: Obstructive sleep apnea (OSA) affects up to 40% of children and adolescents with obesity and the risk for OSA is directly correlated with obesity severity. Several studies have pointed out that OSA per se might lead to metabolic derangement including worsening of insulin resistance, hyperglycemia, and hepatic steatosis. However, the pathophysiologic mechanisms underpinning these associations remain unclear, especially in pediatric groups. The mai...