hrp0084fc-lb-4 | Late Breaking Abstracts | ESPE2015

Long-Term Cognitive Effects of Antenatal Dexamethasone Treatment in Swedish Adolescents with and without CAH

Wallensteen Lena , Zimmermann Marius , Sandberg Malin Thomsen , Nordenstrom Anna , Hirviskoski Tatja , Lajic Svetlana

Background: In order to prevent virilization in CAH female fetuses, physicians have during the last thirty years used the synthetic glucocorticoid dexamethasone (DEX) as a therapeutic approach administered during early pregnancy. Due to the fact that treatment has to be started before the genotype of the fetus is known, seven out of eight treated fetuses will be subjected to high doses of DEX during early embryogenesis without benefit. Therefore, negative side effects cannot b...