hrp0084p3-813 | Endocrine Oncology | ESPE2015

Metabolic Syndrome in Childhood Acute Lymphoblastic Leukaemia Survivors

Delvecchio Maurizio , Luce Vincenza , Monteduro Mariantonietta , Giordano Paola , Muggeo Paola , Santoro Nicola , Cavallo Luciano , Faienza Maria Felicia

Background: A significant number of long-term complications are reported in childhood acute lymphatic leukemia (ALL) survivors, and among them metabolic syndrome (MetS).Objective and hypotheses: To evaluate the prevalence of features of MetS. In addition, we evaluated the presence of steatohepatitis which is described in association with MetS in otherwise healthy subjects.Method: We assessed waist circumference, triglycerides level...

hrp0095p1-242 | Diabetes and Insulin | ESPE2022

The lncOb rs10487505 polymorphism impairs insulin sensitivity and glucose tolerance in children and adolescents with obesity

Rosaria Umano Giuseppina , Cirillo Grazia , Rondinelli Giulia , Vittoria Foderini Maria , Ferrara Serena , Di Sessa Anna , Marzuillo Pierluigi , Santoro Nicola , Miraglia del Giudice Emanuele

Purpose: Leptin plays a key role in the regulation of body weight and other endocrine systems. Recently, impairment of leptin gene transcription due to genetic variations in a long-noncoding RNA, also referred as lncOb, has been described in mice. In humans, a correspondent polymorphism (rs10487505) has been associated with relatively low plasmatic leptin levels compared to obesity severity and with early obesity onset.Objectives...