hrp0086p1-p46 | Adrenal P1 | ESPE2016

The Effect of Intrauterine Stress on Leukocyte Telomere Length in Newborns

Stefa Alketa , Lamprokostopoulou Agaristi , Kontogeorgou Anna , Briana Despina , Malamitsi-Puchner Ariadne , Tsitsilonis Ourania , Gagos Sarantis , Charmandari Evangelia

Background: Telomeres are specialized nucleoprotein structures located at the ends of chromosomes playing a crucial role in genomic stability. They consist of tandem repeats of the noncoding hexameric TTAGGG sequence. Telomere shortening has been associated with cardiovascular disease, hypertension, type 2 diabetes, atherosclerosis, coronary heart disease and stroke, and has been proposed as a biomarker for ageing and a prognostic factor for age-associated diseases.<p clas...