hrp0098p3-223 | Pituitary, Neuroendocrinology and Puberty | ESPE2024

Use of Desmopressin Instead of CRH for Inferior Petrosal Sinus Sampling in Children with Clinical Suspicion of Cushing’s Disease

Kelestemur Elif , Kurt Ilknur , Topcuoglu Melih , Onal Hasan , Ceylan Savas , Yapici Ozge , Dagcinar Adnan , Guran Tulay

Context: Corticotropin-releasing hormone (CRH)-stimulated inferior petrosal sinus sampling (IPSS) has an important role in the differential diagnosis of hypercortisolism of pituitary or ectopic origin as the most accurate procedure in terms of sensitivity and specificity compared with clinical, biochemical and imaging analyses. However, due to the cost and unavailability issues of CRH, desmopressin may be an alternative to CRH during IPSS.<p class="abstext...