hrp0094p1-176 | Growth Hormone and IGFs B | ESPE2021

Irisin in the growth hormone deficient children: before and on rhGH therapy.

Seifert Monika , Noczynska Anna , Wikiera Beata ,

Introduction: In recent years, one of the most frequently studied focuses is the pathophysiology of adipose and muscle tissue; however, in the literature there is no report about regulatory proteins (myokines/adipomyokines), which expression affects the body’s metabolism and communication between tissues especially in children population. Irisin (Ir) is one of the adipomyokines, which induces the conversion of white adipocytes into beige adipose tissue, a...

hrp0092rfc12.2 | Growth and Syndromes (to include Turner syndrome) | ESPE2019

Treatment with Growth Hormone Increases Klotho Concentration in Patients with Turner Syndrome

Wikiera Beata , Seifert Monika , Nocon-Bohusz Julita , Noczynska Anna , Daroszewski Jacek

Background: Short stature, increased adiposity and insulin resistance are conditions frequently observed in patients with Turner syndrome (TS). Many hormones are involved in the pathogenesis of the condition but therapeutic options we can offer to the patients are still scant. Each newly discovered peptide give us hope. Klotho play a very important role in the regulation of the human body metabolism and was not investigated in patients with TS so far.<p cl...

hrp0089p1-p148 | GH &amp; IGFs P1 | ESPE2018

GH Treatment Causes an Increase in Klotho Concentration in Children with Growth Hormone Deficiency

Wikiera Beata , Seifert Monika , Nocon-Bohusz Julita , Noczynska Anna , Daroszewski Jacek

Introduction: Klotho is a protein which may serve as a regulator of GH secretion. Growth hormone deficiency is diagnosed in children with growth restriction when GH secretion in two GH stimulation tests do not exceed the level of 10 ng/ml.Aim: The objective of the study was to investigate Klotho and FGF23 in children with growth hormone deficiency (GHD) and their responce to the treatment with recombinant human growth hormone (rHGH).<p class="abstext...