hrp0094p2-413 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2021

Challenges faced by children and adolescents with Differences in Sex Development (DSD) managed at a tertiary care specialized university center in Sri Lanka

Jayakody Chamath , Seneviratne Sumudu

Introduction: DSDs encompass a heterogenous group of conditions associated with multiple medical and psychosocial challenges. There is a paucity of data from patients from relatively low resource settings, where difficulties faced and their management may differ based on the different socio-cultural background. Objectives: To describe the underlying condition, presentation, medico-social issues, problems and challenges, and their management in a cohort o...

hrp0094p2-428 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2021

Case series: Use of tamoxifen in the management of gynaecomastia in three adolescent boys with 46 XY DSD

Jayakody Chamath , Seneviratne Sumudu

Background: Management of gynaecomastia in adolescent males with Partial Androgen Insensitivity Syndrome (PAIS) remains a clinical conundrum. The main mode of treatment is mastectomy, while literature on pharmaceutical management is limited. This case series evaluates outcome of 3 children treated with tamoxifen. Case 1: A 16-year-old-boy with genetically confirmed PAIS, presented with bilateral gynaecomastia at 11 years of age. He had severe under-viril...

hrp0086p2-p77 | Adrenal P2 | ESPE2016

Management Dilemmas in a Genetically Female Child with Congenital Adrenal Hyperplasia Raised as a Male

Seneviratne Sumudu , Samarasinghe Malik , de Silva KSH

Background: Conventionally, 46 XX infants with congenital adrenal hyperplasia (CAH) were reared as females, even if considerably virilised at birth. However, lately there has been some debate on this stance, and male gender of rearing is also being considered.Objective and hypotheses: We report on a 9 year old genetically female child (N) with salt wasting CAH reared as a male, with precocious female puberty, currently suppressed with GnRH analogs, and d...

hrp0086p1-p929 | Thyroid P1 | ESPE2016

Neonatal Thyrotoxicosis and Craniosynostosis Associated with Maternal Graves’ Disease and High Dose maternal Thyroxine Therapy for Papillary Carcinoma

Seneviratne Sumudu , Lucus Nishani , Weerasinghe Ashangi

Background: Neonatal Graves’ disease (NGD) occurs in 1–2% pregnancies with maternal Graves’ disease. Thyroid auto-antibodies can persist in the maternal circulation even 10 years after thyroidectomy and can lead to NGD in the absence of maternal thyrotoxicosis. Both maternal stimulating autoantibodies and maternal thyroxine can cross the placenta, and have been implicated in neonatal craniosynostosis.Objective and hypotheses: We report a c...

hrp0097p1-207 | Adrenals and HPA Axis | ESPE2023

Health-Related Quality of Life in Children with Congenital Adrenal Hyperplasia: A Systematic Review and Meta-Analysis

Seneviratne Sumudu , Gunawardena Shamaali , Jayarajah Umesh , Ahmed Faisal

Introduction: Congenital adrenal hyperplasia (CAH) is a lifelong condition associated with long term medical and psychosocial issues, which can adversely affect Quality of Life (QoL). There is paucity of high-grade evidence on health-related QoL in children and adolescents with CAH, with available studies being limited by small study samples. We conducted a systematic-review(SR) and meta-analysis(MA) to assess factors associated with health-related QoL among c...

hrp0097p1-376 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2023

Obtaining clear birth certificates for children with difference in sex development (DSD) undergoing sex reassignment: A new legal process for Sri Lanka

Seneviratne Sumudu , Jayakody Chamath , Hewakuruppu Sathee , Wickremesekere Dinusha , Jayasundere Ramani

Introduction: Majority of births in Sri Lanka occur in hospitals, with birth registration completed prior to discharge. When babies with atypical genitalia are missed at birth, and gender re-assignment decided, following later detection and evaluation, families faced many challenges to obtain a “clear” birth certificate (BC), without incriminating details of prior name or sex.Objectives: To describe character...

hrp0097p2-65 | Diabetes and Insulin | ESPE2023

Systematic review on the effects of the COVID-19 pandemic on incidence of new-onset type 1 diabetes (TID), and glycemic control among children/ adolescents with pre-existing TID

Seneviratne Sumudu , Thalompita Malintha , Pallegama Chamathka , Karunathilake Chamathni , Jayarajah Umesh

Introduction: There is some evidence to suggest that the SARS-CoV-2 virus affects endocrine organs and metabolic processes. However much of the available evidence involves adults. We conducted a systematic review to summarise recent evidence on the effects of COVID-19 on the incidence and disease control of type I diabetes mellitus (T1DM) among children and adolescents.Method: We conducted a literature search up to 05/03...

hrp0097p2-242 | Late Breaking | ESPE2023

Endocrine manifestations of the COVID-19 pandemic in children and adolescents: a scoping review

Seneviratne Sumudu , Pallegama Chamathka , Karunathilake Chamathni , Thalompita Malintha , Jayarajah Umesh

Introduction: There is limited data on endocrine manifestations of the COVID-19 pandemic in children/adolescents. We conducted a scoping review to summarize available evidence.Method: A literature search was conducted using PubMed, Scopus and Google Scholar databases to identify studies on endocrine manifestations of COVID-19 in children/adolescents, published up to 31/03/2023 using pre-specified keywords, and perusing a...

hrp0086p1-p455 | Fat Metabolism and Obesity P1 | ESPE2016

Seven-year Follow-up of Mothers from a Randomized Controlled Trial of Exercise in Pregnancy and their Offspring

Chiavaroli Valentina , Hopkins Sarah , Derraik Jose , Seneviratne Sumudu , Biggs Janene , Rodrigues Raquel , Cutfield Wayne , Hofman Paul

Background: We have previously shown in a randomised controlled trial that moderate-intensity exercise over the last 20 weeks of gestation in healthy nulliparous women led to a birth weight reduction of approximately 250 g.Objective and hypotheses: We aimed to assess the long-term effects of exercise in pregnancy on anthropometry and body composition in mothers and offspring 7 years after the intervention. We hypothesized that women who exercised in preg...

hrp0086p2-p588 | Perinatal Endocrinology P2 | ESPE2016

Case Report on Hyperinsulinism/hyperammonaemia Syndrome: An Easily Treatable Cause of Postprandial Hypoglycaemia

Seneviratne Sumudu , Jayatunge Tharanga , Atapattu Navoda , De Silva K. S. H. , Wickramasinghe V. P. , De Silva Harendra

Background: Hyperinsulinism/hyperammonaemia (HI/HA) syndrome is associated with postprandial hypoglycaemia and mild hyperammonemia. There is increased insulin release following protein ingestion, which is amenable to diaxozide therapy. While developmental delay and normoglycaemic seizures can also occur, hepatomegaly has not been reported. We report a child with HI/HA and hepatomegaly, mild learning difficulty and obesity, who was initially mistaken to have glycogen storage di...