hrp0098p2-51 | Bone, Growth Plate and Mineral Metabolism | ESPE2024

Real-world experience with vosoritide treatment in achondroplasia: A single-center report from Turkey

Abali Saygin , Sebnem Ozkose Gulsah , Akgun-Dogan Ozlem , Semiz Serap , Alanay Yasemin

Introduction: Vosoritide, a C-type natriuretic peptide analog, has emerged as the first therapeutic agent approved to enhance growth velocity in individuals with achondroplasia (ACH).Aim: To assess growth response to vosoritide in children with ACH under the care of a specialized multidisciplinary team (MDT).Methods: A retrospective study was conducted in our center on children dia...

hrp0098rfc14.2 | Fetal and Neonatal Endocrinology | ESPE2024

Does gestational diabetes mellitus influence mitochondrial dynamics in offspring?

Abali Saygin , Oz-Arslan Devrim , Guner-Yilmaz Bengisu , Celik Musa , Koç Berkcan , Muftuoglu Meltem , Pata Ozlem , Korkmaz-Toygar Ayse , Semiz Serap , Kan Beki , Beken Serdar

Introduction: Gestational diabetes mellitus (GDM) is a common problem in pregnancy with metabolic consequences for the fetus and the postnatal period. The aim of this study was to investigate the effects of GDM on mitochondrial structure and function in cord blood mononuclear cells and placental tissue, and the relationship between clinical data and mitochondrial dynamics.Method: In this prospective cohort study, singlet...