ESPE Abstracts

Background: Recent studies suggest that osteocalcin (OC) promotes glucose and lipid metabolism via ACAM, integrin αVβ3, GLUT1 and GLUT8 expression, directly affecting adipocytes. OC represents a link between bone and glucose metabolism; it stimulates insulin and stimulates pancreatic β-cells proliferation through Gprc6a receptor. Low levels of OC were observed in adult patients with Type 2 DM suggesting an association with glucose into...