hrp0089p3-p375 | Thyroid P3 | ESPE2018

Congenital Hypothyroidism – Diagnose Early and Keep Going

Sergeyev Elena , Sloltze Anette , Kiess Wieland , Pfaeffle Roland , Koerner Antje

Background: Serious mental and physical retardation are sequelae of untreated congenital hypothyroidism. These complications have become rare since the introduction of neonatal screening in Germany.Case report: Here we report about a girl with congenital hypothyroidism, who suffered from extreme short and thickset stature, rough facial features and straw-like hair at the age of 12 years. She had been detected in newborn screening with a TSH of 132 IU/ml....

hrp0082fc12.4 | Obesity | ESPE2014

Pediatric Reference Values for Insulin from oGTT and Prevalence of Hyperinsulinemia in Obese Children

Korner Antje , Scheuermann Kathrin , Neef Madlen , Sergeyev Elena , Vogel Mandy , Kratzsch Jurgen , Kiess Wieland

Background: Evaluation of glucose metabolism is currently based on 2 h glucose during an oral glucose tolerance test (oGTT) or fasting glucose and insulin or A1c, as these are the only parameters where cutoff values exist. This does, however, not adequately reflect the degree of hyperinsulinemia due to insulin resistance in obese children.Objective and design: From frequent glucose and insulin levels during an oGTT of 64 healthy lean children (aged 7.7&#...

hrp0089p2-p142 | Fat, Metabolism and Obesity P2 | ESPE2018

Children with Obesity are Taller in Early Childhood with Subsequent Catch-down Growth Until Adolescence

Kempf Elena , Vogel Tim , Kratzsch Jurgen , Vogel Mandy , Landgraf Kathrin , Sergeyev Elena , Kiess Wieland , Stanik Juraj , Korner Antje

Context: Childhood obesity is supposed to affect growth and development in children but there is uncertainty with regard to dynamics and potential causes. We analyzed differences in age-related growth patterns of obese and normal-weight children and their association with circulating endocrine and metabolic factors.Objective/Design: In a large German childhood cohort from Leipzig including 7986 children (22793 data sets) we compared cross-sectional and l...