hrp0098p1-4 | Adrenals and HPA Axis 1 | ESPE2024

The Role of Endogenous Opioids (EOPs) in Ischaemic Pre-Conditioning (IPC) in Humans

Muhammad Shahid

Background: Timely reperfusion of ischaemic tissue is prerequisite to improve outcomes of CVD, but paradoxically reperfusion causes injury to tissues. This concept is referred to as ischaemia-reperfusion (IR) injury. Studies are thriving to better understand IR injury and develop novel treatments to minimise this. One such approach is termed ischaemic preconditioning (IPC) which entails brief periods of alternating ischaemia and reperfusion prior to t...