hrp0082p1-d3-87 | Diabetes (2) | ESPE2014

The Natural Evolution of Impaired Glucose Homeostasis Among Obese Adolescents in a High – Risk Diabetes Prone Population

Zuckerman-Levin Nehama , Pasternak Idit , Najjar Sami , Hermoni Doron , Shehadeh Naim

Background: Obesity is increasing worldwide among adults, children and adolescents. The increase in obesity rates facilitated the development of several morbidities including impairment in glucose homeostasis. T2DM is described mainly among minority groups, and in Israel it is more frequent among the Arab population.Objective and hypotheses: We hypothesized that a correlation exists between the degree of obesity and impaired glucose homeostasis among Ara...

hrp0092p1-32 | Diabetes and Insulin | ESPE2019

Heterozygous RFX6 Mutation as a Cause of Diabetes Mellitus in a Multigenerational Family

Zuckerman Levin Nehama , Paperna Tamar , Hershkovitz Tova , Mory Adi , Kurolap Alina , Mahameed Jamal , Feldman Hagit Baris , Shehadeh Naim

Background: Monogenic diabetes mellitus (DM) is an early-onset, non- autoimmune diabetes. Genetic diagnosis can personalize patient management and lead to prevention. We describe four generations of DM in one family, caused by a heterozygous mutation in the RFX6 gene. RFX6 (Regulatory factor X, 6) is essential for the development of the endocrine pancreas. Mutations in RFX6 can cause neonatal (Mitchell-Riley syndrome) as well as childhood DM,...

hrp0089rfc12.3 | Diabetes and Insulin 2 | ESPE2018

Barriers and Sources of Support for the Performance of Physical Activity in Pediatric Type 1 Diabetes

Livny Ruth , Said Wasim , Shilo Smadar , Gal Shoshana , Oren Meirav , Weiss Ram , Zuckerman-Levin Nehama , Shehadeh Naim , Cohen Michal

Background: The advantages of physical activity are particularly emphasized in children with type-1-diabetes and 60 minutes of regular daily activity is recommended. However, reports suggest that children with type-1-diabetes perform less than the recommended daily activity and are less active than their non-diabetic peers. This study aimed to: i) Identify barriers and sources of support for exercise performance in children and adolescents with type-1-diabetes. ii) Identify st...

hrp0084p1-40 | Diabetes | ESPE2015

Efficacy and Safety of a Fixed Combination of Insulin Degludec/Insulin Aspart in Children and Adolescents with Type 1 Diabetes

Battelino Tadej , Deeb Larry , Reiter Panagiota Diamantopoulou , Greve Tina Maria , Klingensmith Georgeanna , Kocova Miriana , Kovarenko Margarita , Shehadeh Naim

Background: Insulin degludec/insulin aspart (IDegAsp) is the first soluble co-formulation that combines two insulin analogues.Aims and objectives: To assess the efficacy and safety of IDegAsp administered once-daily (OD) plus meal-time IAsp for remaining meals in controlling glycaemia as assessed by change in HbA1c from baseline in a paediatric population.Methods: A 16-week, 1:1, open-label, parallel group, randomised, t...