hrp0089p2-p402 | Thyroid P2 | ESPE2018

Association of Thyroid Stimulating Hormone and Free Thyroxine with Cardiometabolic Risk Factors in Euthyroid Korean children and Adolescents Aged 10–18 Years: The Korean National Health and Nutrition Examination Survey 2015

Lim Jung Sub , Shim Young Suk , Kim Eun Young

Objective: The present study aimed to evaluate the association of free thyroxine (FT4) and TSH with insulin resistance indices in euthyroid Korean children and adolescents using nationally representative data.Methods: A total of 259 children and adolescents were included in data from The Korean National Health and Nutrition Examination Survey 2015.Results: TSH levels were significantly positively associated with HOMA-IR (β...

hrp0089p1-p103 | Fat, Metabolism and Obesity P1 | ESPE2018

Associations of Non-High-Density Lipoprotein Cholesterol with Metabolic Syndrome and Its Components in Korean Children and Adolescents: the Korea National Health and Nutrition Examination Surveys 2008–2014

Shim Young Suk , Jeong Hwal Rim , Yang Seung , Kim Eun Young , Hwang Il Tae

Background: In this study, we aimed to investigate the relationship between single-gender Korean references for non-high-density-lipoprotein cholesterol (non-HDL-C) and metabolic syndrome (MetS) in childhood.Methods: A total of 5,742 Korean children aged 10–18 years who participated in a national survey were included. The subjects were classified into three groups based on single-gender non-HDL-C levels as follows: <120 mg/dl (desirable), &#8805...

hrp0089p3-p218 | GH &amp; IGFs P3 | ESPE2018

Bone Age Maturation During the Three Years of GH Treatment in Patients with Idiopathic GH Deficiency and Idiopathic Short Stature: Analysis of Data from LG Growth Study

Shim Young Suk , Hwang Il Tae , Yang Seung , Kim Eun Young

Background: Although the beneficial effects of GH treatment on statural growth are well known, the impacts on skeletal maturation are not fully understood. In the current study, we aimed to investigate the progression of bone age (BA) in children with idiopathic GH deficiency (iGHD) and idiopathic short stature (ISS) based on a LG Growth Study (LGS). We also evaluated the progression rate of BA relative to chronologic age (CA) between iGHD and ISS and to find their associated ...

hrp0089p1-p207 | Pituitary, Neuroendocrinology and Puberty P1 | ESPE2018

Urinary Gonadotropins as a Useful Non-invasive Marker of Central Precocious Puberty

Hwang Il Tae , Jeong Hwal Rim , Yang Seung , Shim Young Suk

Aims: The current study aimed that first morning voided (FMV) urinary gonadotropin measurements could be used as a noninvasive alternative to the gonadotropin-releasing hormone (GnRH) test in the assessment of the hypothalamic-pituitary-gonadal function in children.Methods: In a multi-center study, we compared FMV urinary gonadotropin concentrations with GnRH-stimulated serum gonadotropin levels in 140 girls aged 7–9 years who were evaluated for pub...

hrp0082p3-d1-881 | Perinatal and Neonatal Endocrinology | ESPE2014

A Case of Hyperinsulinism/Hyperammonemia Syndrome

Shim Young Suk , Jeong Hwal Rim , Lee Hae Sang , Lim Jung Sub , Hwang Jin Soon

Background: Hyperinsulinism/hyperammonemia (HI/HA) syndrome is a form of congenital hyperinsulinism (CHI) caused by a mutation in the GLUD1 gene. It is characterized by hyperinsulinemic hypoglycemia accompanying hyperammonemia.Objective and hypotheses: We report HI/HA syndrome with a 4-month-old male who hypoglycemic seizure.Method: A 4-month-old male infant presented with seizure caused by fasting-induced hypoglycemia. At the time...

hrp0082p3-d3-947 | Puberty and Neuroendocrinology (1) | ESPE2014

The Etiology of Central Precocious Puberty and Effect of GnRH Agonist for 2 years in Korean Boys

Shim Young Suk , Jeong Hwal Rim , Lee Hae Sang , Lim Jung Sub , Hwang Jin Soon

Background: GnRH agonist (GnRHa) are able to modify natural course of Central Precocious Puberty (CPP) in girls.Objective and hypotheses: We evaluated the etiology and the effect of GnRHa in Korean CPP boys.Method: Total 29 boys diagnosed for CPP from 2007 to 2012 were included in Ajou University Medical Center. Sellar MRI was performed in 26 of 29 patients (89.7%). CPP was diagnosed on the basis of i) onset evidence of testicular ...

hrp0084p3-876 | Fat | ESPE2015

Obesity has a Significant Impact on Hyperandrogenemia Only after Puberty in Korean Girls

Kang Min Jae , Shim Young Suk , Oh Yeon Joung , Hwang Il Tae , Yang Seung

Background: As metabolic complication and polycystic ovarian syndrome due to childhood obesity is rising, the role of hyperandrogenemia (HA) and hyperinsulinism is receiving attention.Objective and hypotheses: The aim of this study was to investigate the presence or absence of obvious HA according to pubertal status and to find potential etiologic determinants of HA in Korean obese girls.Method: We analysed 91 subjects aged 6–...

hrp0084p3-925 | GH &amp; IGF | ESPE2015

Influence of the -202 A/C IGFBP3 Promoter Polymorphism on Individual Variation in Body Height in Korean Girls

Yang Seung , Shim Young Suk , Kang Min Jae , Oh Yeon Joung , Hwang Il Tae

Background: The most common single nucleotide polymorphism in the IGFBP3 promoter region occurs at position -202. This polymorphic variation occurs frequently and may influence GH responsiveness and somatic growth.Objective and hypotheses: This study aimed to assess the effects of IGFBP3 promoter polymorphism on growth in children.Method: Restriction fragment length polymorphism (RFLP)-based genotyping of the -202 single nucleotide...

hrp0084p3-1138 | Puberty | ESPE2015

Psychosocial Changes after GnRH Agonist Treatment in Girls with Idiopathic Central Precocious Puberty

Yang Seung , Shim Young Suk , Kang Min Jae , Oh Yeon Joung , Hwang Il Tae

Background: In precocious puberty, girls experienced secondary sexual development earlier psychologically as well as physically. Self-stress due to a different body shape from the peer group, psychological concerns due to discrepancies between physical and chronological age, and long-term behavioural problems could occur.Objective and hypotheses: The aim of this study was to evaluate psychosocial changes in girls with precocious puberty between before an...

hrp0094p1-63 | Diabetes B | ESPE2021

Comparison of triglyceride and glucose index and homeostatic model assessment for insulin resistance in children and adolescents with type 2 diabetes mellitus

Seo Yoon Jong , Kim Eun Young , Yi Kyung Hee , Shim Young Suk , Hwang Il Tae ,

Background: Triglyceride and glucose (TyG) index is significantly associated with higher risk of developing type 2 diabetes mellitus (T2DM). The mechanism of the role of TyG index in the development of T2DM is not clear. There are few studies on the relationship between the TyG index and homeostatic model assessment of insulin resistance (HOMA-IR).Aims: To elucidate the role of the TyG index, studies are needed on the association between...