hrp0097fc6.5 | Pituitary, neuroendocrinology and puberty 1 | ESPE2023

Clinical characteristics of 213 children with early pubertal development complicated with pineal cyst

Yuan Shuxian , Lin Yifan , Zhao Yixuan , Chen Yongxing , Wei Haiyan

Background: Previous studies have speculated that melatonin secreted by the pineal gland plays a role in the regulation of puberty, and pineal cyst may affect its secretory function, thus causing early pubertal development. However, there are few studies on early pubertal development with pineal cyst and its clinical features are not clear. This study aims to explore its clinical features and the relationship with cyst size to further improve the understanding...

hrp0097p1-164 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Insight into Gut Microbiota of Normal Body Mass Index Girls with Idiopathic Precocious Puberty

Lin Yifan , Fu Dongxia , Yuan Shuxian , Wei Haiyan

Key words: precocious puberty; idiopathic central precocious puberty; premature thelarche; gut microbiota; HPG axisBackground: The incidence of precocious puberty and obesity has increased significantly after the COVID-19 epidemic, and the specific cause is not clear. There seems to be a causal relationship between obesity and idiopathic central precocious puberty. A few studies have shown that the changes of gut microbi...

hrp0097rfc6.1 | Pituitary, neuroendocrinology and puberty 1 | ESPE2023

Clinical application of LH cut-off value in the diagnosis of CPP according to the international consensus

Lin Yifan , Zhang Yingxian , Fu Dongxia , Yuan Shuxian , Hou Yuwei , Wei Haiyan

Keywords: Central precocious puberty; Luteinizing hormone; Precocious puberty Gonadotropin-releasing hormone agnosit testBackground: 2019 International consensus on central precocious puberty (CPP) proposed that random serum luteinizing hormone (LH) ≥0.83IU/L and < 0.2IU/L has important reference value for the establishment or exclusion of CPP, but there is no corresponding diagnostic criteria in China. This study ...

hrp0097p1-219 | Bone, Growth Plate and Mineral Metabolism | ESPE2023

An investigation of vitamin D deficiency in children with new onset type 1 diabetes mellitus from Henan Province, China

Chen Qiong , Yuan Shuxian , Chen Yongxing , Li Tao , Yang Wei , Huang Ai , Liu Fang , Cao Bingyan , Wei Haiyan

Several observational studies have reported vitamin D deficiency (VDD) in children with type 1 diabetes mellitus (T1DM). The investigation of VDD in children with new onset T1DM in China is lacking. The current study aimed to assess vitamin D status and examine the factors that influence VDD in children with new onset T1DM in Henan Province, China. Children with new onset T1DM (n=280) and healthy controls (n=710) were enrolled in Henan Province. Demographic a...