hrp0095rfc3.5 | Early Life and Multisystem Endocrinology | ESPE2022

Chronotropic Insufficiency impairs Cardiorespiratory Fitness in Boys and Adolescents with Klinefelter Syndrome

Spiekermann Julia , Höppner Jakob , Sinningen Kathrin , Hanusch Beatrice , Brinkmann Folke , Schündeln Michael M. , Kleber Michaela , Kiewert Cordula , Grasemann Corinna

Background: Klinefelter syndrome (KS) is associated with an increased metabolic and cardiovascular risk profile1,2 and a metabolic syndrome is evident at a prepubertal age in 10% of the affected boys. Boys with KS tend to avoid competitive sports and describe themselves as ‘not good at sports’. Cardiopulmonary fitness in adults with KS has been found to be compromised by chronotropic insufficiency (CI) and a reduced maximal oxygen uptake...