hrp0082p3-d3-938 | Puberty and Neuroendocrinology (1) | ESPE2014

Hyperandrogenism Doesn’t Increase the Insulin Resistance in Overweight and Obese Adolescent Girls with Polycystic Ovary Syndrome

Smetanina Natalija , Seibokaite Audrone , Valickas Raimondas , Verkauskiene Rasa

Background: Polycystic ovary syndrome (PCOS) is associated with metabolic abnormalities and increased insulin resistance (IR), which is closely associated with abdominal obesity and hyperandrogenism in adults. Some studies indicate that hyperandrogenism influences insulin resistance development in PCOS patients. Data on PCOS association with risks of metabolic disorders in adolescence are scars.Objectives: In this study we aimed to investigate androgen p...

hrp0084p2-381 | Fat | ESPE2015

Metformin in Combination with Lifestyle Changes Effectively Reduces BMI and Waist Circumference in Overweight/Obese Children and Adolescents

Smetanina Natalija , Seibokaite Adrone , Valickas Raimondas , Kuprionis Gintaras , Grigoniene Jolanta Janina , Rokaite Ruta , Vitkauskiene Astra , Albertsson-Wikland Kerstin , Verkauskiene Rasa

Background: Overweight (OW) and obesity in paediatric population has been shown to be associated with an increase in prevalence of insulin resistance and type 2 diabetes (T2D) in youth.Objective and hypotheses: The aim of this study was to assess the efficiency and safety of metformin use in combination with lifestyle changes or alone for weight management in OW and obese (OB) children and adolescents.Methods: Study included 145 10...

hrp0082p2-d1-515 | Pituitary | ESPE2014

High Prevalence of PROP1 Gene Defects Among Patients with Multiple Pituitary Hormone Deficiency in Lithuania

Navardauskaite Ruta , Dusatkova Petra , Obermannova Barbora , Pfaeffle Roland W , Blum Werner F , Adukauskiene Dalia , Smetanina Natalija , Cinek Ondrej , Verkauskiene Rasa , Lebl Jan

Background: Mutations in PROP1 are the most common known genetic cause of congenital multiple pituitary hormone deficiency (MPHD).Objective and hypotheses: Aim of our study was to clinically and genetically characterize a cohort of Lithuanian patients with MPHD.Method: Seventy-six Lithuanian MPHD patients were tested for PROP1 gene by Sanger sequencing. Hormonal investigations, pituitary imaging and GH therapy wer...