hrp0089p2-p042 | Bone, Growth Plate & Mineral Metabolism P2 | ESPE2018

High Fibroblast Growth Factor (FGF) 23: An Unusual Cause of Severe Osteoporosis in a Patient with Chronic Liver Disease

Ng Nicholas Beng Hui , Lee Yung Seng , Sng Andrew Anjian , Aw Marion Margaret , Loke Kah Yin

Case description: A 14-year old boy with autoimmune hepatitis who was on long term oral steroids for 10 years, presented with acute onset lower back pain without preceding trauma. Lumbar spine radiograph showed severe osteopenia and compression fractures of vertebrae T12 to L1. Bone mineral density T-score at the lumbar region was −4.9. Biochemically, there was hypocalcaemia and severe hypophosphataemia with adjusted calcium 2.03 (2.20–2.65) mmol/l and phosphate 0.8...

hrp0084p3-713 | Diabetes | ESPE2015

Sirolimus Therapy in an Infant with Persistent Hyperinsulinaemic Hypoglycaemia

Lim Yvonne Yijuan , Sng Andrew Anjian , Hussain Khalid , Loke Kah-Yin

Background: Persistent hyperinsulinaemic hypoglycaemia (HH) of infancy (PHHI) is a rare condition which presents with severe hypoglycaemia during the neonatal period. For medically unresponsive forms of diffuse HH, subtotal pancreatectomy was previously the only treatment option, with the potential consequences of recurrence of hyperinsulinism, diabetes mellitus and exocrine pancreatic insufficiency. The novel use of sirolimus treatment was recently reported in four infants wh...

hrp0092p3-1 | Adrenals and HPA Axis | ESPE2019

A Case of Cushing Syndrome in a Wilms' Tumour

Lim Yvonne Yijuan , Sng Andrew Anjian , BH Ng Nicholas , Ho Wei-li Cindy , Loke Kah-yin , Lee Yung-seng

Paraneoplastic Cushing syndrome is extremely rare. To date, there are few reported cases related to Wilms' tumor. We describe a patient who presented with Cushing syndrome and was subsequently found to have Wilms' tumor. Our patient is a 9 year-old boy, who presented with hyperphagia and excessive weight gain for 3 months. His abdomen was also progressively bigger. There was no ingestion of steroids or traditional medication. Subsequently he sought medical advice becau...