hrp0095p1-336 | Multisystem Endocrine Disorders | ESPE2022

Prevalence of Short Stature and Endocrinopathy in β-thalassemia Major Patients on Conventional Therapy in the Mediterranean and the Middle East countries

Soliman Ashraf , Soliman Nada , Elalaily Rania

Blood transfusion and iron chelation are conventional treatments for β-thalassemia (BTM). However, iron overload in parenchymal organs and endocrine glands still occurs in a good number of these patients.Objective: To evaluate the prevalence of iron-related complications (short stature, growth retardation, and growth hormone deficiency) in BTM.Methods: We performed an electronic search in PubM...

hrp0095p2-97 | Fat, Metabolism and Obesity | ESPE2022

Linear growth and prevalence of the different components of the metabolic syndrome (MetS) in young obese nondiabetic children (below 5 years) in comparison to older obese children (6-12 years)

Hamed Noor , Soliman Ashraf

Introduction: In Qatar, the prevalence of metabolic syndrome (MetS) in children and adults is increasing in parallel with the markedly increasing trends in obesity rates. We studied the prevalence of different components of MetS, measure plasma atherogenic indexes (AIP), and linear growth in young obese nondiabetic children (< 5 years) in comparison to older obese children (6-12 years).Methods: We analyzed the anthrop...

hrp0095p2-135 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2022

Incidence of neonatal hypoglycemia in Qatar: A 3-year study

Soliman Ashraf , Ali Hamdy

Neonatal hypoglycemia is the most common endocrine abnormality in children, which is associated with increased morbidity and mortality. The burden and risk factors of neonatal hypoglycemia in Qatar are suggested to be high because of the high prevalence of gestational diabetes.Objective: To determine the incidence of neonatal hypoglycemia in Qatar in relation to the etiology (infants of diabetic mothers (IDM) vs infants of nondiabetic mo...

hrp0092p3-50 | Diabetes and Insulin | ESPE2019

Hybrid Diabetes with Good Response to Metformin in an Adolescent with Polyglandular Polyendocrinopathy (APS2)

Hamed Noor , Soliman Ashraf

Introduction: Development of type 1 diabetes is well known in cases of type 2 autoimmune polyglandular syndrome (APS). We describe a case of APS2 who developed a hybrid form of diabetes that responded to metformin therapy.Case: The patient is a 17.5 year old male patient who has been diagnosed with APS2 at the age of 13 years with primary adrenal insufficiency and autoimmune hypothyroidism .he has been on treatment with ...

hrp0092p3-139 | GH and IGFs | ESPE2019

Responses to Growth Hormone (GH) Therapy in Children with Short Stature with Normal GH Secretion and Slow Growth Velocity

Elawwa Ahmed , Soliman Ashraf

Background: Variability still exist about the growth response to growth hormone (GH) therapy in children with idiopathic short stature We describe the growth response to GH therapy ( 0.05 mg/kg/day) for > 2 years in 20 prepubertal children with idiopathic short stature (ISS) who had slow growth velocity ( < -1 SD), normal GH response to provocation and who were significantly shorter than their mid-parents height SDS MPHtSDS (-1 difference).<p class...

hrp0089p3-p192 | GH &amp; IGFs P3 | ESPE2018

Good Growth Response to Growth Hormone Therapy in Short Children with Normal Growth Hormone Secretion

Awwa AhmedEl , Soliman Ashraf

The availability of biosynthetic growth hormone (GH) ensures that children who are deficient can have replacement therapy, but it also has created the opportunity to treat children who are short but do not have a deficiency. Non-GH deficient short stature, without treatment, the height outcomes in most studies have failed to reach mid-parental target height. GH therapy resulted in mixed height outcomes; some reached genetic target height whereas others failed. The aim of this ...

hrp0089p3-p268 | Multisystem Endocrine Disorders P3 | ESPE2018

Glycemic Abnormalities and Normal Thyroid Function in Adolescent Survivors of Childhood Acute Lymphocytic Leukemia Who Required Repeated Packed Red Cell Transfusion During Treatment

Soliman Ashraf , Yassin Mohamed

Introduction: Packed red blood cell (PRBC) transfusions are an essential component of leukemia treatment regimens. Transfusion-induced iron overload can be seen after approximately 10 to 20 transfusions. Very little is known about transfusion-related iron burden in oncology populations and its possible effect on endocrine function and glycemia.Patients and methods: We evaluated growth parameters and endocrine disorders in relation to the iron overload st...

hrp0089p2-p394 | Thyroid P2 | ESPE2018

Early Medullary Thyroid Carcinoma (MTC) in an Infant with Multiple Endocrine Neoplasia Type 2B (MEN2B, RETS Mutation codon 891)

Alkhalaf Fawziya , Soliman Ashraf

Introduction: An age-related progression from C-cell hyperplasia to medullary thyroid carcinoma (MTC) is associated with various germ-line mutations in the rearranged during transfection (RET) proto-oncogene that could be used to identify the optimal time for prophylactic surgery. In 207 patients from 145 families there was a significant age-related progression from C-cell hyperplasia to MTC. Thus, early diagnosis and prevention are particularly crucial....

hrp0086p1-p261 | Diabetes P1 | ESPE2016

Johansson-Blizzard Syndrome with Pan-hypopituitrism, Type 2 Diabetes and Pancreatic insufficiency: Effect of Treatment

Alyafie Fawzia , Soliman Ashraf

Background: Johanson-Blizzard syndrome (JBS) is a disease characterized by poor growth, variable dysmorphic features, including aplasia or hypoplasia of the nasal alae, sensori-neural deafness, abnormal hair patterns or scalp defects, and oligodontia. Other features of JBS include pan-hypopituitarism, imperforate anus, and PI. Pancreatic endocrine insufficiency (PI).Case study: AM is a 10 years-old boy, born at term with aplasia of the alae nasi and cong...

hrp0086p2-p842 | Syndromes: Mechanisms and Management P2 | ESPE2016

Linear Growth in Infants and Children with Atopic Dermatitis

Ehlayel Mohamed , Soliman Ashraf

Introduction: Skin barrier defects play central role in the pathogenesis of atopic dermatitis (AD) affecting local immunity and skin hydration. Severe AD may deleteriously affect growth and nutrition in these children.Objectives: To 1) measure the effect of AD on linear growth in infants and children 2) to study the effect of hypoalbuminemia and hypo-proteinemia on the growth of these children.Methods: We studied linear growth and ...