hrp0095p1-140 | Multisystem Endocrine Disorders | ESPE2022

Prevalence of Endocrinopathies in Sickle cell Disease Patients on Conventional Therapy: Review of literature in the past 25 years

Soliman Ashraf , Alaaraj Nada , Soliman Nada , Bilal Ilham

Methods: We performed an electronic search in PubMed, Google Scholar, and Web of Sciences to evaluate the global prevalence of growth hormone impairment and different endocrinopathies in SCD in all publications in the past 25 years.Results: Sixteen studies were included from 9 countries (USA, Canada, UK, Brazil, Jamaica, Egypt, Turkey, Saudi Arabia, and Bahrain) after 2000. The total number of patients was 1286. Most pat...

hrp0095p1-334 | Multisystem Endocrine Disorders | ESPE2022

Multi-continent comparison of the prevalence of short stature and undernutrition in children and adolescents with homozygous sickle cell disease: Africa, USA, Europe, and Middle East area

Soliman Ashraf , Alaaraj Nada , Soliman Nada , Bilial Ilham

Background: Poor growth and under-nutrition are common in children with sickle cell disease (SCD). This review summarizes evidence of impaired linear growth and weight gain in children with SCD in different regions of the world in the past 25 years.Methods: A literature search was conducted on Medline/PUBMED, Google scholar, and SCOPUS, for studies published in English during the past 25 years, using the keywords sickle ...

hrp0095p1-336 | Multisystem Endocrine Disorders | ESPE2022

Prevalence of Short Stature and Endocrinopathy in β-thalassemia Major Patients on Conventional Therapy in the Mediterranean and the Middle East countries

Soliman Ashraf , Soliman Nada , Elalaily Rania

Blood transfusion and iron chelation are conventional treatments for β-thalassemia (BTM). However, iron overload in parenchymal organs and endocrine glands still occurs in a good number of these patients.Objective: To evaluate the prevalence of iron-related complications (short stature, growth retardation, and growth hormone deficiency) in BTM.Methods: We performed an electronic search in PubM...

hrp0094p2-306 | Growth and syndromes (to include Turner syndrome) | ESPE2021

Growth hormone deficiency (GHD) with high circulating insulin-like growth factor-1 (IGF-1) in an adolescent with celiac disease: Is it IGF-1 insensitivity?

Alaaraj Nada , Soliman Ashraf , Hamed Noor ,

Impaired growth in children with Celiac Disease (CD) results mainly from nutritional deficits. Withdrawal of gluten from the diet is frequently associated with a marked improvement of linear growth. Some CD patients still have impaired growth despite good gluten elimination. GH secretion should be evaluated in CD patients showing no catch-up growth. We describe a case with CD and severe linear growth retardation due to possible IGF-1 resistance.Case Pres...

hrp0092p2-296 | Thyroid | ESPE2019

Progressive thyroid dysfunction in infants with Down Syndrome; Trisomy 21 (DS): Effect on Linear Growth

Alaaraj Nada , Soliman Ashraf , Mohammed Shayma , Itani Maya , Khalil Ahmed

Hypothyroidism is the most frequent thyroid abnormality in DS. It can be either congenital, with or acquired at any age after birth. It can be clinical or subclinical disorder. More evidence is required regarding the progressive development of thyroid dysfunction with age.Aim and Methods: We measured thyroid function (Free T4 and TSH) and Anti TPO level in 37 infants with DS at birth, during their first year and after ~ 2.5 years of...

hrp0092p3-153 | Growth and Syndromes (to include Turner Syndrome) | ESPE2019

Prevalence of Thyroid Dysfunction and Associated Autoimmune Disorders in Young Children with Down Syndrome (DS); A Cohort Study.

Alaaraj Nada , Soliman Ashraf , Itani Maya , Mohammed Shayma , Khalil Ahmed

There is an intriguing association between DS and thyroid abnormalities, which include sub-clinical, overt hypothyroidism, hyperthyroidism, and positive thyroid Antibodies. The prevalence of these abnormalities varies considerably depending on the diagnostic criteria and the selected population which includes sample size and age group.Aim: To measure the prevalence of thyroid dysfunction and associated autoimmunity in children with Down ...

hrp0092p3-161 | Growth and Syndromes (to include Turner Syndrome) | ESPE2019

The Effect of Thyroxine Treatment on Linear Growth and Weight Gain in Infants and Children with Down Syndrome (DS) and High TSH Versus Children with DS and Normal Thyroid Function: A Controlled Study

Alaaraj Nada , Soliman Ashraf , Itani Maya , Mohammed Shayma , Khalil Ahmed

Background: Subclinical hypothyroidism is the most common in DS. Thyroxin administration to improve growth early in life is still controversial.We measured linear growth (BMI, height SDS (HtSDS) and weight gain/day ) in 3 groups of infants and young children with Down syndrome (trisomy 21) and divided them retrospectively into 3 groups according to their thyroid function. Group 1 (n = 25) with normal FT4 and TSH, group 2 (n = 20)...

hrp0094p2-415 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2021

Obesity, ovarian mass, vaginal bleeding and hypothyroidism in a 5-year-old female girl

Alhemaidy Noora , Alaaraj Nada , Soliman Ashraf , Hamed Noor , Ahmed Shayma

Introduction: Van Wyk-Grumbach Syndrome (VWGS) is a constellation of symptoms including precocious puberty without adrenarche, delayed bone age, ovarian cysts, and hypothyroidism.Case report: We report here a five-year-old girl who presented for evaluation of obesity, abdominal distension, vaginal bleeding, and abdominal distention. Her HtSDS =-1.3 and BMI SDS =1.5. A large abdominal mass was palpable. She had no breast development or pubic hair. Her Inv...

hrp0094p2-279 | Growth and syndromes (to include Turner syndrome) | ESPE2021

The Effect of Hospital Admission and Nutritional Rehabilitation (NR) on Growth and Metabolic abnormalities in adolescent females with severe Anorexia Nervosa (AN)

Al-Ansari Alanoud , Alsafi Athba , Alaaraj Nada , Soliman Ashraf ,

There is a lack of clear evidence-based guidelines for hospital admission of adolescents with anorexia nervosa (AN), resulting in a high degree of variation in practices. Acceptable indications for admission include the following: weight is less than 75% of ideal body weight, temperature < 35.5°C, heart rate < 50 beats/min, systolic BP <80 mm Hg, and orthostatic change in pulse or in BP.The aim of this study: To evaluate the ant...

hrp0094p2-378 | Pituitary, neuroendocrinology and puberty | ESPE2021

The effect of 3 years of Gonadotropin-Suppressive Therapy in Girls with Early Puberty: Height Z Score in Relation to Mid-Parental height Z score.

Alaaraj Nada , Soliman Ashraf , Hamed Noor , Ahmed Shayma , Alyafei Fawzia ,

Introduction: Early and fast puberty (EFP) in girls, defined as pubertal onset at age 8-9 yr., with an accelerated course, may cause compromised final adult height (FAHt). Treatment with a gonadotropin-suppressive agent is still controversial because the improvement in FAHt is equivocal and there may be a risk of overweight.Aim of the study: We analyzed the data of 24 girls with EFP treated with GnRH analog (GnRH) since Tanner stage 2-3,...