hrp0095p2-151 | GH and IGFs | ESPE2022

A novel mutation of LHX3 is associated with combined hypopituitarism and dysmorphic face

Noorian Shahab , Savad Shahram , Saffari Fatemeh , Nikkhah Saeed , Talea Ali , Soltani Hedieh

The pituitary gland is a pea-sized organ located at the base of the brain. It synthesizes, and secretes, many hormones that control growth and development, and the functioning of the other endocrine glands. Panhypopituitarism is a condition of inadequate or absent production of all these hormones. LHX3 (LIM Homeobox 3) is a Protein-Coding gene involved in pituitary development. Mutations in this gene may result in a deficiency of multiple pituitary hormones. Here, we present a...