hrp0095p1-375 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022
Dubois Vanessa
, Ciancia Silvia
, Claessens Frank
, Craen Margarita
, El Kharraz Sara
, Kim Nari
, Klink Daniel
, Sommers Vera
, Vanderschueren Dirk
, Cools Martine
Background: The increasing number of transgender adolescents presenting in early puberty requires to investigate the effects of long-term puberty suppression and gender-affirming hormones (GAH) on body composition and metabolism. Clinical studies have ethical and practical limitations. A preclinical mouse model may be helpful to gain mechanistic insights.Methods: Prepubertal (4week-old) female mice were treated with the ...