hrp0095rfc5.4 | Adrenals and HPA Axis | ESPE2022

Increased resting-state functional connectivity in the medial orbitofrontal cortex of patients with autoimmune Addison's disease

van't Westeinde Annelies , Padilla Nelly , Bensing Sophie , Lajic Svetlana

Background: Patients with autoimmune Addison’s disease (AAD) lack production of glucocorticoids (GCs), mineralocorticoids (MCs) and androgens from the adrenal gland, due to autoimmune destruction of its cortex. Patients require replacement of GCs and MCs for the rest of their lives. In some cases, testosterone is supplemented in females. Brain function is sensitive to fluctuations in cortisol and may therefore be affected in AAD due to long-term disturba...