ESPE Abstracts

Background: The pathogenesis of autoimmune thyroid diseases depends on many factors including genetic predisposition and environmental factors. Graves' disease and Hashimoto's thyroiditis are associated with an impaired immunological tolerance to antigen molecules in the thyroid gland. Abnormal immunotolerance results from impaired suppression involving regulatory T cells in peripheral immunocompetent tissues (Tregs). It is known that patients with a...

Background: Many epigenetic factors, including microRNAs, are involved in the process of changing gene expression. MiRNAs are small non-coding RNA molecules that regulate gene translation by silencing or degrading target mRNAs. They are recognized as novel diagnostic and prognostic biomarkers for many diseases. Patients with autoimmune thyroid diseases are more likely to develop nodules in the thyroid tissue, and Hashimoto's thyroiditis and Graves’ ...