hrp0097fc6.6 | Pituitary, neuroendocrinology and puberty 1 | ESPE2023

Serum Kisspeptin and DLK1 levels as a tool for diagnosis and monitoring of central precocious puberty treatment in Thai girls

Onsoi Witchuwan , Numsriskulrat Nattakarn , Srilanchakon Khomsak , Aroonparkmongkol Suphab , Supornsilchai Vichit

Background: Kisspeptin and Delta-like 1 homolog (DLK1) are neuropeptides that regulate pubertal timing by activating and inhibiting the hypothalamic-pituitary-gonadal axis; consequently, measuring these biomarkers could potentially distinguish central precocious puberty (CPP) from premature thelarche (PT) girls and monitor CPP treatment.Objectives: To compare baseline serum kisspeptin and DLK1 levels in girls with CPP at...

hrp0098p1-15 | Bone, Growth Plate and Mineral Metabolism 1 | ESPE2024

Adipokines level and vertebral fracture in children and adolescent with systemic lupus erythematous receiving glucocorticoid therapy

Wangwarawut Kulisara , Sukhupanyarak Pemiga , Aroonparkmongkol Suphab , Chowichian Monthira , Srisuwan Konggrapun , Subun Chantida , Phatarakijnirund Voraluck

Background: Adipokines have been demonstrated to regulate bone metabolism and impact bone strength. Previous studies have investigated the potential influence of leptin and adiponectin on the risks of vertebral fracture (VF) and bone mineral density (BMD) in healthy children and postmenopausal women, however, the outcomes of these investigations remain controversy.Objectives: To determine plasma leptin and adiponectin le...