hrp0098fc4.2 | Adrenals and HPA Axis 1 | ESPE2024

11-oxygenated androgens are abundantly produced by first and second-trimester foetal adrenal glands in ex vivo culture

Idkowiak Jan , Melau Cecilie , E Taylow Angela , Juul Anders , T Mitchell Rod , Arlt Wiebke , Jørgensen Anne

Background: Previous descriptions of the steroidogenic capacity of human foetal adrenal glands in an ex vivo culture system focused on the classic androgen pathway and the alternative DHT pathway. However, no information is available on the abundance and role of the adrenal-derived 11-oxygenated androgens during foetal development, and how their levels correlate to classic androgens.Aim: To characterise the ster...