ESPE Abstracts

Introduction: Adamantinomatous craniopharyngioma (aPCs) are complex intracranial neoplasms that arise in the sellar or parasellar region affecting the endocrine system, leading to severe comorbidities. Activating mutations resulting in degradation resistant b-Catenin have been shown to be the main driver for a large proportion of these neoplasms. However, the underlying genetic driver for a number of these tumours remains unknown. Here, using murine transgenic...