hrp0098p1-132 | Fat, Metabolism and Obesity 2 | ESPE2024

The proteome of circulating exosomes in appropriate- versus small-for-gestational-age infants: differentially expressed proteins at birth associate with measures of weight gain, liver fat, insulin resistance and adrenarche at age 7

Díaz Marta , Quesada Tania , Villarroya Francesc , López-Bermejo Abel , Casano Paula , de Zegher Francis , Ibáñez Lourdes

Introduction: Exosomes are extracellular vesicles whose cargo includes proteins that may influence the function of distant cells. It is unknown, however, whether there are differentially expressed proteins (DEPs) in the circulating exosomes of appropriate- vs small-for-gestational-age (AGA vs SGA) infants at birth and, if so, whether such DEPs relate to measures of endocrine-metabolic health and body composition in childhood.Subj...