hrp0092p1-406 | Pituitary, Neuroendocrinology and Puberty (2) | ESPE2019

Tolvaptan for Management of Intractable Salt and Water Imbalance in a Case with Suprasellar Tumor after Surgery

Yamaguchi Tomoe , Terashita Shintaro , Kinjo Kenichi , Fujisawa Yusuke , Yoshii Keisuke , Naiki Yasuhiro , Horikawa Reiko

Background: It is sometimes difficult to diagnose and manage fluid and electrolyte imbalance after surgery for hypothalamic/pituitary tumors. We present a pediatric case of severe SIADH successfully treated with tolvaptan after suprasellar tumor resection.Case: The case was 8-year-old girl with growth failure. She was found to have suprasellar tumor on CT scan when she accidentally fell down and hit her head. MRI suggest...

hrp0098p1-86 | Pituitary, Neuroendocrinology and Puberty 1 | ESPE2024

Comprehensive study on central precocious puberty: molecular and clinical analyses in 90 patients

Kagami Masayo , Narusawa Hiromune , Ogawa Tomoe , Yagasaki Hideaki , Nagasaki Keisuke , Urakawa Tatsuki , Saito Tomohiro , Soneda Shun , Sano Shinichiro , Mamada Mitsukazu , Terashita Shintaro , Dateki Sumito , Narumi Satoshi , Naiki Yasuhiro , Horikawa Reiko , Ogata Tsutomu

Background: Defects of MKRN3, DLK1, KISS1, and KISS1R and some disorders, such as Temple syndrome (TS14), cause central precocious puberty (CPP). Furthermore, MECP2 was reported as a causative gene for CPP in 2023. To our knowledge, comprehensive studies on (epi)genetic abnormalities, clinical features, and hormonal features in patients with CPP have not been reported.Methods: In 90 CP...