hrp0084p3-918 | GH & IGF | ESPE2015

Are Short Children with Low GH Secretion Metabolically Different from Children of Normal Height?

Tidblad Anders , Ekstrom Klas , Ritzen Martin , Marcus Claude

Background: Severe GH deficiency (GHD) leads to several metabolic effects in the body ranging from abnormal body composition to biochemical disturbances such as high insulin sensitivity. However, less is known regarding these parameters in children with a milder deficiency in GH secretion.Objective and hypotheses: To analyse if short children with a relatively low GH secretion differ metabolically from healthy children of normal height.<p class="abst...

hrp0092p2-162 | GH and IGFs | ESPE2019

Metabolic Effects of Growth Hormone Treatment in Short Prepubertal Children: A Double-Blinded Randomized Clinical Trial

Tidblad Anders , Gustafsson Jan , Marcus Claude , Ritzén Martin , Ekström Klas

Objective: Growth hormone (GH) is a central hormone for regulating linear growth during childhood and also highly involved in metabolism of lipids, carbohydrates and protein. However, few studies report on how treatment with GH during childhood influences metabolic parameters. Our aim was to investigate metabolic effects of different doses of GH in short children with GH peak levels in the low normal range.Design: Thirty...