hrp0086fc10.1 | Perinatal Endocrinology | ESPE2016

CYP11B1 Deficiency in Very Preterms: Evidence for an Adrenal Cortex Zone-Specific and Developmental-Dependent Maturation

Travers Simon , Martinerie Laetitia , Boileau Pascal , Lombes Marc , Pussard Eric

Background: Unlike term neonates, known to exhibit a physiological pseudohypoaldosteronism, very preterms (VPT) display a high sodium waste at birth with partial aldosterone deficiency. This context, combined with a low aldosterone/renin ratio is highly suggestive of a defect in mineralocorticoid biosynthesis.Objectives and hypotheses: To investigate mineralocorticoid and glucocorticoid pathways in newborns, and to clarify the impact of prematurity upon ...