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hrp0098fc7.5 | GH and IGFs | ESPE2024

Use of overnight GH sampling in the diagnosis of growth disorders in children: neuroimaging findings and response to treatment

Mainieri Francesca , Cerbone Manuela , Caiulo Silvana , Gan Hoong-Wei , Tulsidas Dattani Mehul

Background: The diagnosis of GH deficiency is challenged by the suboptimal accuracy of GH stimulation tests. Overnight GH sampling (OGS) may be useful in the diagnosis of growth disorders.Objectives: To establish if 1) the reduced number of spontaneous overnight GH profile peaks (SOGPP) is associated with hypothalamo-pituitary (H-P) abnormalities on MRI, 2) these children benefit from GH treatment....

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hrp0098p1-107 | Adrenals and HPA Axis 2 | ESPE2024

Non-invasive biochemical monitoring for Congenital Adrenal Hyperplasia: use of urinary steroid metabolites and salivary 17α-Hydroxyprogesterone

J Tonge Joseph , Bacila Irina , Richard Lawrence Neil , Alvi Sabah , D Cheetham Timothy , Crowne Elizabeth , Das Urmi , Tulsidas Dattani Mehul , H Davies Justin , Gevers Evelien , Keevil Brian , E Krone Ruth , Patel Leena , Randell Tabitha , J Ryan Fiona , Thankamony Ajay , Faisal Ahmed S , Taylor Norman , P Krone Nils

Background: Monitoring disease control in congenital adrenal hyperplasia (CAH) by random serum 17a-Hydroxyprogesterone (17OHP) measurements is invasive and fails to capture total daily adrenal steroid synthesis. Urinary steroid analysis may provide a more suitable, non-invasive method of assessing treatment response in children with CAH, by estimating the total daily excretion of 17OHP metabolites.Method: Urine was colle...

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ESPE Abstracts

Use of overnight GH sampling in the diagnosis of growth disorders in children: neuroimaging findings and response to treatment

Non-invasive biochemical monitoring for Congenital Adrenal Hyperplasia: use of urinary steroid metabolites and salivary 17α-Hydroxyprogesterone

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