hrp0097p2-182 | Diabetes and Insulin | ESPE2023

Evaluation of clinical outcomes in children and adolescents with type 1 diabetes switching from Insulin Glargin to Insulin Detemir

Turan Hande , Kaya Didem , Ercan Oya

Basal-bolus insulin therapy is currently, the most common treatment modality in children and adolescents with type 1 diabetes mellitus (T1DM) worldwide. Insulin glargine and detemir are two different molecules, produced with small modifications, of human insulin. In this prospective longitudinal study, we aimed to compare HbA1c, time in range in CGM, basal insulin doses and hypoglyccemia frequencies in children and adolescents with T1DM who underwent switching from insulin det...

hrp0095p1-496 | GH and IGFs | ESPE2022

The Effect of Anastrozole Treatment on Height Gain in Pubertal Boys on Growth Hormone Treatment

Tarçın Gürkan , Koç Çalışgan Cansu , Turan Hande , Ercan Oya

Introduction: In children receiving growth hormone (GH) therapy during puberty, epiphyseal fusion due to sex steroids often limits the height gain. Aromatase inhibitors may seem to help at this point despite the lack of evidence. Herein, it was aimed to investigate the efficacy of anastrozole for add-on treatment in pubertal male patients receiving GH therapy.Methods: This is a retrospective study comparing two groups of...

hrp0094p2-292 | Growth and syndromes (to include Turner syndrome) | ESPE2021

Timing of infancy-childhood growth spurt in healthy Turkish children

Sharifova Sabina , Turan Hande , Tarcin Gurkan , Sharifli Samir , Gur Emel , Ercan Oya ,

Aim: The onset of the infancy-childhood growth spurt (IC spurt) is identical with the onset of the childhood component of the infancy-childhood-puberty growth model. The aim of this study was to determine the timing of IC spurt and to investigate the factors affecting it in healthy children.Materials and Methods: The files of 231 healthy children who were followed up regularly (at 0, 2, 4, 6, 12, 15, 18, 24, 30 and 36 months) at the Ista...

hrp0095p1-454 | Diabetes and Insulin | ESPE2022

Clinical and genetic evaluation of patients with maturity onset diabetes of the young (MODY) : Single center experience

Hande Turan , Bayramoglu Elvan , Gunes Kaya Didem , tarcin Gürkan , Bingöl Aydın Dilek , Ercan Oya , Evliyaoglu Olcay

Purpose: MODY is a monogenic diabetes with autosomal dominant inheritance that usually occurs in adolescence or young adulthood. It constitutes 1% of diabetes cases in childhood. The diagnosis of MODY is very difficult due to genetic heterogeneity, rarity, and clinical overlap with other diabetes types. In recent years, the diagnosis of MODY has become easier with genetic developments. On the other hand, misinterpretation of results can cause confusion. In thi...

hrp0095p1-457 | Diabetes and Insulin | ESPE2022

Rabson Mendenhall Syndrome: A Rare Insulin Resistance Syndrome

Bingöl Aydın Dilek , Tin Oğuzhan , Bayramoğlu Elvan , Turan Hande , Evliyaoğlu Olcay , Ercan Oya

Introduction: Rabson-Mendenhall Syndrome (RMS) is an autosomal recessive, extremely rare, serious insulin resistance syndrome that occurs as a result of mutation in the insulin receptor (INSR) gene. Pathogenic variants in the INSR gene cause a broad spectrum of inherited insulin resistance syndromes. Here, a male case who presented with the complaint of diffuse acanthosis nigricans and was diagnosed with RMS is shared. Case Repor...

hrp0089p2-p106 | Diabetes & Insulin P2 | ESPE2018

Congenital Hyperinsulinism: Clinical and Molecular Characteristics – Fluorine-18-L-Dihydroxyphenylalanine Positron Emission Tomography (F-DOPA PET) Scan Results – Treatment Responses and Short Term Outcomes of 5 Patients

Turan Hande , Dagdeviren Cakir Aydilek , Cayir Atilla , De Franco Elisa , Ellard Sian , Sonmezoglu Kerim , Ercan Oya , Olcay Evliyaoglu Saadet

Aim: The most common cause of persistent hypoglycemia and related brain damage in infancy is congenital hyperinsulinism (CHI), due to inappropriate secretion of insülin by pancreatic ╬▓cells. The most frequent and most serious mutations are activating mutations in ABBC8 or KCNJ11 genes. Genetic analyses, which might predict the type of lesion, performed in early period and 18f dopa pet scanning are very valuable for treatment choice and follow-up of the patients. In t...

hrp0097fc6.2 | Pituitary, neuroendocrinology and puberty 1 | ESPE2023

The role of body composition and appetite-regulating hormones in idiopathic central precocious puberty and their changes during GnRH analogue therapy.

Tarçın Gürkan , Bayramoğlu Elvan , Güneş Kaya Didem , Karakaş Hasan , Turan Hande , Evliyaoğlu Olcay

Aim: This study aimed to compare the levels of appetite-regulating hormones (ghrelin, leptin, peptide-YY (PYY), neuropeptide-Y (NPY)) in girls with idiopathic central precocious puberty (ICPP) before treatment with prepubertal girls, and to evaluate changes in these hormone levels and body composition during leuprolide acetate (LA) treatment.Methods: This prospective, cross-sectional study included girls with ICPP, isola...

hrp0097p1-11 | Adrenals and HPA Axis | ESPE2023

Girls with Premature Adrenarche but not SGA Reach Their Target Height

Bingöl Aydın Dilek , Tin Oğuzhan , Turan Hande , Bayramoğlu Elvan , Ercan Oya , Evliyaoğlu Olcay

Introduction:Premature adrenarche (PA) is the most common cause of premature pubic and axillary hair growth before the age of 8 in girls. At the time of diagnosis, the height and bone age of the cases with premature adrenarche were determined to be higher than their peers. The long-term effects of advanced bone age on the final length of the cases are controversial. In this study, it is aimed to share the long-term follow-up data of the cases diagnosed with pr...

hrp0095p1-475 | Fat, Metabolism and Obesity | ESPE2022

The Impact of Acute Exercise on 12,13-Dihydroxy-9Z-Octadecenoic Acid (12,13-DiHOME) Levels in Male Adolescents with Obesity

Ercan Oya , Gurup Aybüke , Tarçın Gürkan , Yakal Sertaç , Turan Hande , Şahinler Ayla Sibel , Boztürk Güngör Zeynep

Aim: 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME) is a lipokine secreted from brown adipose tissue, and it is shown to have positive effects on dyslipidemia. Acute exercise have been shown to lead to an increase in its secretion. It was aimed to investigate the relation of 12,13-diHOME with obesity, exercise and dyslipidemia for the first time in the adolescent age group.Methods: This is a prospective study includ...

hrp0092p2-5 | Adrenals and HPA Axis | ESPE2019

Clinical Phenotype and Genotype Association in Patients with 21-hydroxylase Deficiency

Aghayeva Asmar , Turan Hande , Toksoy Guven , Dagdeviren Cakir Aydilek , Berkay Ezgi , Gunes Nilay , Evliyaoglu Olcay , Uyguner Zehra Oya , Dundar Munis , Tuysuz Beyhan , Ercan Oya

Introduction: Congenital adrenal hyperplasia (CAH) is an autosomal recessively transmitted disease and 95% of CAH cases are due to 21-hydroxylase deficiency (21-OHD). There are more than 100 mutations that cause CAH due to 21-OHD and the clinical expression of the disease is reported to correlate with mutated alleles.The aim: The aim of this study was to investigate responsible mutations and then to evaluate genotype...