hrp0092p1-11 | Adrenals and HPA Axis | ESPE2019

Assessment of the Adrenal Function in Children with Acute Lymphoblastic Leukemia Before and After Induction Therapy with Corticosteroids

Dhawi Naji Walad , Khater Doaa , Al-Yaarubi Saif , Ullah Irfan Ullah , Wali Yasser

Background: Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Corticosteroids are the cornerstone in treatment of pediatric ALL. Steroids can cause several side effects including secondary adrenal insufficiency with disruption of cortisol response to stress causing morbidity and even mortality in those children.Objective: To assess the adrenal gland function of children with ALL before and after i...

hrp0092p1-222 | GH and IGFs (1) | ESPE2019

A Patient with a Novel Homozygous Mutation in IGF1-R Gene and Response to Growth Hormone Therapy

Nasser Al Shidhani Azza , Al-Kindi Adila , Ullah Irfan , Al Saffar Hussein , Al Yaarubi Saif

Background: There are multiple factors affecting fetal growth, including maternal, fetal, placental and other environmental factors. Insulin like growth factor-1 ( IGF-1) has a major role in promoting fetal and post-natal growth. It is also proven that IGF1 promote brain, inner ear and retinal development.Case: We report a 9-years old boy born at 31 weeks of gestation to a consanguineous parents by cesarean section for s...

hrp0092p3-20 | Adrenals and HPA Axis | ESPE2019

Short Synacthen Test in Children at Sultan Qaboos University Hospital; Reviewing the Sampling Times

Alsaffar Hussain , Alshafey Mohammed , Ullah Irfan , Al-Riyami Nafila , Alyaarubi Saif , Al-Shidhani Azza

Introduction: Primary adrenal insufficiency in paediatrics is uncommon but lethal condition, it results most commonly from congenital adrenal hyperplasia1. Short Synacthen Test (SST) is widely used to assess the glucocorticoid synthesis in the adrenal glands. Synacthen doses are age-based; 62.5mcg for babies younger than 6months, 125mcg for infants between 6-24months and 250mcg for children older than 2years. There is a controversy amongst endocrino...

hrp0092p3-76 | Diabetes and Insulin | ESPE2019

Extra Attention to be Paid When Looking After Boys with Type 1 Diabetes Mellitus in Oman

Alsaffar Hussain , Alrawahi Athila , Alhubaishi Zumaima , Alshukaili Maha , Ullah Irfan , Alhinai Shaima , Alshidhani Azza , Alyaarubi Saif

Introduction: More than 1,106,500 worldwide children were living with type1 diabetes mellitus (T1DM) in 20171. Researchers concluded that better glycaemic control is associating with lesser complications of this chronic condition. Target HbA1c is recommended to be <48mmol/mol(<6.5%) and <53mmol/mol(<7%) as per NICE and ISPAD respectively2. The glycaemic control represented by HbA1c was worse amongst the British gir...

hrp0089p3-p174 | Fetal, Neonatal Endocrinology and Metabolism P3 | ESPE2018

Congenital Hyperinsulinism and Maple Syrup Urine Disease a Challenging Combination

Shidhani Azza Al , Murshedi Fathiya Al , Yaarubi Saif Al , Thihli Khalid Al , Ullah Irfan

Background: Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infancy, characterized by unregulated insulin secretion. CHI is a challenging disease to diagnose and manage. Moreover, complicating the course of the disease with another metabolic disease like Maple syrup urine disease (MSUD) adds more challenges to the already complex management.Case: We report a term male neonate with uneventful birth ...

hrp0094p2-11 | Adrenals and HPA Axis | ESPE2021

Rare Presentation of Adrenal Insufficiency in an Infant with Holocarboxylase Synthetase Deficiency

Al-Farsi Aws , Qureshi Tabinda Naz , Ullah Irfan , Al-Rahbi Najwa , Abdwani Raghad Al , Al-Musalhi Buthaina , Al-Thihl Khalid , Al-Shidhani Azza , Alsaffar Hussain ,

Introduction: Adrenal insufficiency can be caused by different factors. Biotin deficiency is either nutritional or related to synthesis/recycling defects. We are reporting a rare case of adrenal insufficiency complicating a late diagnosis of holocarboxylase synthetase deficiency in an infant who also had protein-S-deficiency, later thought to be secondary.Case: Term female infant born, to non-consanguineous parents, in good condition wit...