hrp0092p1-289 | Thyroid (1) | ESPE2019

Thyroid Peroxidase Antibodies in Children with HLA-Conferred Susceptibility to Type 1 Diabetes

Saare Liisa , Peet Aleksandr , Tillmann Vallo

Introduction: The prevalence of thyroid peroxidase antibody (anti-TPO) positivity is estimated to be around 3-4% in healthy children and is remarkably higher in children with type 1 diabetes (T1D). However, anti-TPO positivity in children with HLA-conferred susceptibility to T1D who are not yet diagnosed with T1D, is not well studied. The aim of this study was to describe the prevalence of positive anti-TPO and its effect of thyroid function in children wi...

hrp0089p2-p378 | Thyroid P2 | ESPE2018

The Prevalence of Clinically Significant Anti-TPO Positivity in Children with HLA-Conferred Susceptibility to Type 1 Diabetes

Saare Liisa , Peet Aleksandr , Tillmann Vallo

Background: The increased prevalence of anti-thyroid peroxidase antibodies (anti-TPO) and autoimmune thyroiditis in children with type 1 diabetes (T1D) has been previously well described. However, the necessity for screening for anti-TPO in children who have not been diagnosed with T1D yet, but have a HLA-conferred susceptibility to T1D, has not been reported. A 3% prevalence of anti-TPO in healthy children has been shown in studies using a cut-off value of >100 kU/L for c...

hrp0095p1-453 | Diabetes and Insulin | ESPE2022

Usability of CGM for hyperglycemia detection during systemic glucoriticoid treatment.

Lukka Mari , Tillmann Vallo , Peet Aleksandr

Glucocorticoids are widely used to treat autoimmune and inflammatory diseases. The side-effects of glucocorticoids are well known, but not routinely monitored in the pediatric population. Recommendations regarding the timing of blood glucose screening are lacking and understanding about the correlation between different glucocorticoid treatment regimens and glucose variability is insufficient. Our objective was to test the usability of continuous glucose monitooring (CGM) to d...

hrp0086p1-p480 | Fat Metabolism and Obesity P1 | ESPE2016

Associations of Different Appetite Hormones with Physical Activity and Cardiorespiratory Fitness in Adolescent Boys with Different BMI Values

Tillmann Vallo , Remmel Liina , Purge Priit , Latt Evelin , Jurimae Jaak

Background: Higher physical activity (PA) attenuates the health risks of obesity and has positive effects on body weight reduction. The results of our recent longitudinal study showed that PA, especially vigorous PA (VPA), is an important factor for predicting overweight in boys during puberty (Lätt et al., 2015).Objective and hypotheses: The aim of this study was to examine the associations of fasting serum acylated and des-acylated ghreli...

hrp0082p2-d2-600 | Thyroid (1) | ESPE2014

Low Serum Free T4 Concentration in a Girl with McCune-Albright Syndrome

Peet Aleksandr , Roosimaa Mart , Pajuvali Anett , Tillmann Vallo

Background: McCune–Albright syndrome (MAS) is a rare disease with a prevalence of <1 to 100 000. It is caused by early post-zygotic mutations in the GNAS1 gene. Classically it presents with precocious puberty, fibrous dysplasia and café-au-lait spots. Other endocrinopathies may be hyperthyroidism, GH excess, Cushing syndrome, and renal phosphate wasting.Case report: A 17-year-old girl diagnosed with MAS at the age of 11 on basis of all thre...

hrp0094p1-16 | Bone A | ESPE2021

Leptin to adiponectin ratio at the age of 12 is negatively associated with lumbar spine bone mineral apparent density independently of body fat mass in 18-year old males.

Tamme Reeli , Jurimae Jaak , Maestu Evelin , Remmel Liina , Purge Priit , Mengel Eva , Tillmann Vallo ,

Background: Inconsistent associations of leptin and adiponectin with bone mineral characteristics in puberty and adolescence have been reported.Aim: To examine associations between leptin to adiponectin ratio (LAR) in puberty and bone mineral characteristics at 18 years of age and increase of bone mineral characteristics until 18 years of age.Materials and methods: 88 boys were investigated with a ...

hrp0092p1-17 | Bone, Growth Plate and Mineral Metabolism | ESPE2019

Serum Testosterone Level at the Age of 12 is an Important Determinant of the Following Gain of Bone Mineral Apparant Density in 18-year Old Males: a Longitudinal Study From Puberty

Tamme Reeli , Jürimäe Jaak , Remmel Liina , Mäestu Evelin , Purge Priit , Mengel Eva , Tillmann Vallo

Background: Many cross-sectional studies have demonstrated that serum testosterone concentration is an important biochemical predictor of bone mineral density in young males, but to our knowledge, no longitudinal studies have been carried out to support these cross-sectional data.Aims: to examine the associations between serum testosterone concentration at the age of 12 and the following gain in bone mineral density unti...

hrp0082p1-d3-226 | Reproduction (2) | ESPE2014

Serum Leptin, Ghrelin, and Adiponectin Levels in Relation to Body Composition in Rhythmic Gymnasts Entering into Puberty: a 3-year Follow-up Study

Tillmann Vallo , Vosaberg Kristel , JurimParm Anna-Liisa , Saar Meeli , Jurimae Toivo , Maasalu Katre , Neissaar Inga , Latt Evelin , Jurimae Jaak

The aim: Of this study was to describe longitudinal changes in body composition and serum leptin, ghrelin and adiponectin levels over 36-month period in prepubertal rhythmic gymnasts (RG) and their age-matched untrained controls (UC) entering into puberty.Methods: 35 RG (mean age 8.0±0.6 years) and 33 UC (8.2±0.6 years) were followed at 12-month intervals for the next 3 years. Height, weight, pubertal stage, body composition by DXA and serum le...

hrp0095p1-218 | Bone, Growth Plate and Mineral Metabolism | ESPE2022

Pubertal Increment in Insulin Resistance is Negatively Associated with Lumbar Bone Mineral Density in 18-Year-Old Males Independently of Body Composition

Mengel Eva , Tamme Reeli , Remmel Liina , Purge Priit , Mäestu Evelin , Jürimäe Jaak , Tillmann Vallo

Aim: Insulin resistance is known to be closely related to the development of obesity and type 2 diabetes, whereas transient insulin resistance is part of the physiological developmental processes during pubertal years. However, insulin resistance might have detrimental effect on growing bone and bone mineral accrual. The aim of the present study was to identify whether increase in insulin resistance during pubertal years contribute to bone mineral characterist...

hrp0086p1-p115 | Bone &amp; Mineral Metabolism P1 | ESPE2016

A European Survey to Identify New Roads for Care, Training and Research Around Rare Metabolic Bone Diseases

Fernandez Isabelle , Ahmed Syed Faisal , Bishop Nick , Brandi Maria Luisa , Doulgeraki Artemis , Haeusler Gabriele , Hogler Wolfgang , Kostik Mikhail , Makitie Outi , Moreno Gabriel Martos , Nilsson Ola , Schnabel Dirk , Šumnik Zdenek , Tillmann Vallo , Turan Serap , Zillikens Carola , Linglart Agnes , on behalf of the European Metabolic Bone Network

Background: Rare metabolic bone diseases (RMBD) are at the crossways of Endocrinology, Nephrology, Orthopaedic surgery and Rheumatology. Most of RMBD lead to short stature, bone pain, tooth anomalies, leg deformities, bone fragility and disability of variable importance. The organization of care varies immensely amongst European countries. Several European networks dedicated to RMBD already exist, supported by societies such as ESPE, ECTS or research grants, albeit their focus...