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hrp0092p1-1 | Adrenals and HPA Axis | ESPE2019

Could a Glucocorticoid Receptor Polymorphism be Protective against Hypothalamic-Pituitary-Adrenal Axis Suppression in Asthmatic Children on Corticosteroids?

Akurugu Wisdom Alemya , Van Heerden Carel Jacobus , Vorster Anna Alvera , Lesosky Maia , Mulder Nicola , Zöllner Ekkehard Werner

Background: Homozygotes for the single nucleotide polymorphisms (SNPs) rs242941 and rs1876828 of the corticotrophin-releasing hormone receptor 1 (CRHR1) gene were previously associated with lower stimulated and basal cortisol levels respectively in asthmatic children on inhaled corticosteroids. Heterozygotes for rs41423247 of the glucocorticoid receptor (NR3C1) gene were found to have higher basal cortisol levels.Objectives</stro...

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Could a Glucocorticoid Receptor Polymorphism be Protective against Hypothalamic-Pituitary-Adrenal Axis Suppression in Asthmatic Children on Corticosteroids?

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