hrp0098fc7.4 | GH and IGFs | ESPE2024

Growth Hormone Response to Glucagon Stimulation Test in Transitional Age

Fava Daniela , Vanorio Barbara , Santucci Chiara , Parodi Stefano , Pepe Alessia , Repetto Agnese , Caridi Claudia , Acquarone Lucia , Data Erica , Merlo Silvia , Napoli Flavia , Tedesco Caterina , Angelelli Alessia , Panciroli Marta , Casalini Emilio , Di Iorgi Natascia , Maghnie Mohamad

Context: In the diagnosis of permanent GH deficiency (GHD) during the transition phase, the 2019 AACE guidelines recommended peak GH-cutoffs of ≤3µg/L and ≤1µg/L for the glucagon test (GST), while a recent investigation identified a value <5.8μg/L as a suitable gold standard (Fava et al, Journal of Clinical Endocrinology and Metabolism, 2024). However, the clinical applicability of this cutoff remains to be confirmed and the potential c...