hrp0084p1-125 | Thyroid | ESPE2015

Thyrocyte is Particularly Well Protected Against Oxidative Stress Induced by H2O2

Ghaddhab Chiraz , Van Den Eeckhaute Emmanuel , Hancisse Olivier , Driessens Natacha , Versteyhe Soetkin , Miot Francoise , Dumont Jacques-Emile , Corvilain Bernard

Background: H2O2 produced in large quantities in the thyroid may play a role in the pathogenesis of thyroid nodules and cancer. In vitro, moderate amounts of H2O2 are able to cause similar DNA damage compared to irradiation and even to induce RET/PTC rearrangements.Objective and hypotheses: We compared the defence mechanisms against H2O2 and irradiation in human thyrocytes, T-cell...