hrp0095p1-68 | Fat, Metabolism and Obesity | ESPE2022

Gender variability and associations of blood dopamine, leptin and insulin in overweight children.

Viazava Liudmila , Solntsava Anzhalika

Background: Some neuropeptides and hormones, for instance dopamine, leptin and insulin can affect the food consumption, eating behavior and can lead to obesity. Research goal was to discover the gender differences, associations and joint influence on body weight of blood dopamine (DA), leptin (LP) and insulin (Ins) concentrations in obese children.Material and methods: We discovered cross-sectional retrospective data of ...

hrp0092p3-312 | Late Breaking Abstracts | ESPE2019

Emotional Status Instability and Body Mass Index as Predictive Markers for Dopamine System Dysfunction Evaluation in Pubertal Age Children

Viazava Liudmila , Solntsava Anzhalika , Zaytseva Elena

Study aim was to create a prognostic algorithm of dopamine system dysfunction in pubertal age children, based on emotional instability markers, depending on body mass index and pubertal periods.Materials and Methods: Study subjects comprised 120 children (11.6 – 17.9 y/o, the 2nd – 5th Tanner stages) from Belarusian population between 2015 and 2017. Emotional status instability sings were obtained using th...

hrp0086p2-p523 | Fat Metabolism and Obesity P2 | ESPE2016

Body Image Perception Changes in Obese and Lean Children

Viazava Liudmila , Solntsava Anzhalika , Sukalo Alexander

Background: Body image (BI) is subjective picture of one’s own physical appearance established both by self-observation and by noting the reactions of others. Different BI scales used for screening of the Binge Eating symptoms that strongly linked to obesity.Objective and hypotheses: We supposed to get differences in the own body image perception in overweight and lean children.Method: BI questionnaire (BIQ) and own body satis...

hrp0089p2-p171 | Fat, Metabolism and Obesity P2 | ESPE2018

Gender and Pubertal Tendencies of Plasma leptin and Dopamine Levels Depending on TaqIA DRD2 Gene Polymorphism in the Different Pediatric Obesity Classes

Viazava Liudmila , Solntsava Anzhalika , Aksionava Alena , Dashkevich Alena

Study aim was to evaluate the contribution of DRD2 gene TaqIA polymorphism, plasma leptin and dopamine concentrations to obesity development in children with different adiposity classes, depending on gender and pubertal stage.Materials and methods: 223 children aged from 11 to 17.9 years were involved in the retrospective one-stage analysis, 179 of them were randomly genotyped in the TaqIA of DRD2 gene and blood dopamine (BD) concentrations were detected...

hrp0082p2-d2-375 | Fat Metabolism & Obesity (1) | ESPE2014

Family and Genetic Factors Influence the Metabolic Changes in Children

Solntsava Anzhalika , Viazava Liudmila , Sukalo Alexander , Aksionava Elena , Danilenko Nina

Background: Primary and secondary prevention of childhood obesity is an essential public health priority.Objective and hypotheses: To determine relationships between families, genetic and metabolic obesity risk factors in children.Method: 782 children (204 lean/578 obese; m/f=414/368) aged from 2 to 17.9 years were examined and classified in line with the pubertal stage: 392 prepubertal, 141 early, and 249 late puberty. Family hist...

hrp0082p2-d3-396 | Fat Metabolism & Obesity (2) | ESPE2014

D2 Dopamine Receptor Agonists Influence in the Animal Model of Dietary Obesity

Viazava Liudmila , Solntsava Anzhalika , Sukalo Alexander , Dashkevich Elena , Stukach Yuliya

Background: Increased caloric intake in dietary obesity (DO) could be driven by central mechanisms regulating reward-seeking behavior. Leptin modulates the mesolimbic dopamine system and vice versa.Objective and hypotheses: We supposed D2 dopamine receptor agonists to influence weight gain and leptin level in genetically unmodified rats (GUR) with high caloric diet (HCD) as dietary obesity.Method: Male rats (n=48,...

hrp0084p1-68 | Fat | ESPE2015

Leptin Resistance Alteration after Modulation of Dopamine System Funcional Activity in Rat’s Diet-Induced Obesity

Viazava Liudmila , Solntsva Angzhalika , Sukalo Alexander , Dashkevich Alena , Stukach Julia

Background and aim: High caloric diet (HCD) in diet-induced obesity (DIO) can be caused by central mechanisms regulating reward-seeking behaviour. Leptin modulates the dopamine system and vice versa. We supposed D2 dopamine receptor agonist and dopamine neurons toxin to influence weight gain and leptin level, mobility and behaviour in wild type rats (GUR) with HCD.Materials and methods: Male rats (n=64, 183.0±14.0 g) were divided into HCD g...