ESPE Abstracts

Lipodystrophic syndromes are rare and heterogeneous diseases, characterized by a generalized or partial loss of adipose tissue (lipoatrophy) associated with metabolic complications usually associated with obesity: insulin-resistant diabetes, dyslipidemia, ovarian hyperandrogenism and non-alcoholic fatty liver disease.Molecular genetic studies in different types of lipodystrophies showed that primary adipocyte alterations leading to impaired adipogenesis ...

Background: Lipodystrophy syndromes comprise a group of extremely rare and heterogeneous diseases characterized by a selective loss of adipose tissue in the absence of nutritional deprivation or catabolic state. Because of the rarity of each lipodystrophy sub-form, research in this area requires international co-operation. Therefore, in 2016, the European Consortium of Lipodystrophies (ECLip) decided to create a registry for patients affected by lipodystrophy....