hrp0095p1-242 | Diabetes and Insulin | ESPE2022

The lncOb rs10487505 polymorphism impairs insulin sensitivity and glucose tolerance in children and adolescents with obesity

Rosaria Umano Giuseppina , Cirillo Grazia , Rondinelli Giulia , Vittoria Foderini Maria , Ferrara Serena , Di Sessa Anna , Marzuillo Pierluigi , Santoro Nicola , Miraglia del Giudice Emanuele

Purpose: Leptin plays a key role in the regulation of body weight and other endocrine systems. Recently, impairment of leptin gene transcription due to genetic variations in a long-noncoding RNA, also referred as lncOb, has been described in mice. In humans, a correspondent polymorphism (rs10487505) has been associated with relatively low plasmatic leptin levels compared to obesity severity and with early obesity onset.Objectives...