hrp0094s11.1 | Calcium and Phosphate Beyond Bone | ESPE2021

Phosphate toxicity: focus on medial vascular calcification

Voelkl Jakob ,

Inorganic phosphate is essential for bone stability and various cellular metabolic pathways. Serum phosphate levels are regulated by an endocrine triangle of calcitriol, parathyroid hormone and fibroblast growth factor 23. In addition, a mineral buffering system is required to prevent mineral stress and ectopic calcification by spontaneous precipitation of calcium and phosphate. Current research indicates a complex interplay of phosphate homeostasis and inflammatory processes,...