hrp0095fc4.6 | Fat, Metabolism and Obesity | ESPE2022

Influence of growth hormone status and glucose metabolism on hs-Troponin T and NT-proBNP levels in a cohort of healthy children (The LIFE child study)

Kiess Alexandra , Kiess Wieland , Vogel Mandy

Background and Objectives: N-terminal-pro hormone Brain Natriuretic Peptide (NT-proBNP) and hs-Troponin T (hs-TnT) are commonly used cardiac biomarkers despite lacking a deeper understanding about influencing parameters especially in the healthy pediatric population. We previously found associations between NT-proBNP and hs-TnT and a child´s age, sex, pubertal status, Body Mass Index (BMI) and serum lipid levels. Subsequently, we explored associations wi...

hrp0082fc12.4 | Obesity | ESPE2014

Pediatric Reference Values for Insulin from oGTT and Prevalence of Hyperinsulinemia in Obese Children

Korner Antje , Scheuermann Kathrin , Neef Madlen , Sergeyev Elena , Vogel Mandy , Kratzsch Jurgen , Kiess Wieland

Background: Evaluation of glucose metabolism is currently based on 2 h glucose during an oral glucose tolerance test (oGTT) or fasting glucose and insulin or A1c, as these are the only parameters where cutoff values exist. This does, however, not adequately reflect the degree of hyperinsulinemia due to insulin resistance in obese children.Objective and design: From frequent glucose and insulin levels during an oGTT of 64 healthy lean children (aged 7.7&#...

hrp0089p2-p142 | Fat, Metabolism and Obesity P2 | ESPE2018

Children with Obesity are Taller in Early Childhood with Subsequent Catch-down Growth Until Adolescence

Kempf Elena , Vogel Tim , Kratzsch Jurgen , Vogel Mandy , Landgraf Kathrin , Sergeyev Elena , Kiess Wieland , Stanik Juraj , Korner Antje

Context: Childhood obesity is supposed to affect growth and development in children but there is uncertainty with regard to dynamics and potential causes. We analyzed differences in age-related growth patterns of obese and normal-weight children and their association with circulating endocrine and metabolic factors.Objective/Design: In a large German childhood cohort from Leipzig including 7986 children (22793 data sets) we compared cross-sectional and l...

hrp0097fc9.1 | Diabetes and insulin 2 | ESPE2023

Reference values for the insulin response to glucose challenge enable the early detection of emerging (pre)diabetes in children and young adults with obesity

Stein Robert , Vogel Mandy , Stanik Juraj , Kratzsch Jürgen , Stumvoll Michael , Blüher Matthias , Kiess Wieland , Körner Antje

Background: The course of type 2 diabetes is more severe among children with obesity than among adults. Therefore, children at high risk for glycemic deterioration should be detected early enough to guide preventive (and interventional) clinical management.Methods: We established age- and puberty-specific reference values for 7 different indexes addressing the insulin response during oral glucose tolerance testing upon 4...

hrp0086lbp3 | (1) | ESPE2016

The Growth Hormone – Insulin Like Growth Factor I (IGF-1) System in Early Non-Alcoholic Fatty Liver Disease: From an Animal Model to a Children’s Cohort

de Giorgis Tommaso , Penke Melanie , Schuster Susanne , Grafe Nico , Kiel Alexander , Karlas Thomas , Weigand Johannes , Vogel Mandy , Garten Antje , Antje Korner , Kiess Wieland

Background: Non-alcoholic fatty liver disease (NAFLD) represents one of the most common obesity complications and can progress to non-alcoholic stetohepatitis (NASH). NASH is associated with lower insulin like growth factor I (IGF-1) and IGFBP-3, however no data are available regarding the growth hormone (GH)-IGF-I axis in early stage of NAFLD, characterised by hepatic steatosis.Objective and hypotheses: We aimed to investigate the GH-IGF-1 pathway in a ...

hrp0097p1-256 | Fat, Metabolism and Obesity | ESPE2023

Serum leptin concentrations in a pooled cohort of 6.105 children and adolescents: Reference values as a function of dependence on sex, age, pubertal stage and BMI-SDS

Brandt Stephanie , Vogel Mandy , Kratzsch Jürgen , Tews Daniel , Pridzun Lutz , Flehmig Bertram , B Ranke Michael , Körner Antje , Kiess Wieland , F Blum Werner , Wabitsch Martin

Background: Current reference values for leptin in childhood and adolescence are presented separately for girls and boys, and as a function of age without considering the variability of fat mass. This complicates the interpretation of measured serum leptin concentrations since fat mass is the major determinant of circulating leptin concentrations. To fill this gap, we aimed at pooling existing data (age, BMI, sex, tanner stage (TS), serum leptin concentrations...